Ultra-Sensitive Detection of Protein-Ligand Interactions

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$100,000.00
Award Year:
2003
Program:
SBIR
Phase:
Phase I
Contract:
1R43CA101460-01
Award Id:
65391
Agency Tracking Number:
CA101460
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
BIOSENSE TECHNOLOGIES, INC., 4 ARROW DR, WOBURN, MA, 01801
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
RONALDRIEDER
(781) 933-3635
RIEDER@BIOSENSETECH.COM
Business Contact:
(781) 933-3635
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): The development of an evanescent wave biosensor enabling the monitoring of binding interactions of small weakly interacting bio-molecules (MW<100Da) currently not possible is proposed. This technique relies on an innovative transducer design employing a novel self-compensating interferometer capable of surface sensitivities at the level of fg/mm2 - many orders of magnitude improvement over commercially available biosensors. The device employs the novel use of microfluidic flow dynamics for high capture efficiency further reducing the time to results for high throughput and is readily integrated into a small disposable, sealed cartridge for ease of use and low cost. The Phase I effort is focused around a proof-of-principle experiment demonstrating the sensitivity of the device. The Phase II effort will focus on the development of a microfluidic flow cell and a technical demonstration of the binding of a relevant ligand-protein system.

* information listed above is at the time of submission.

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