NOVEL DEVICES FOR COLLECTING AND PROCESSING MYCOBACTERIA

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$99,994.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43AI052538-01
Agency Tracking Number:
AI052538
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
BIOSEQ, INC.
BIOSEQ, INC., 217 PERRY PKY, GAITHERSBURG, MD, 20877
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
NATHAN LAWRENCE
(301) 208-8100
MLAWRENCE@BBII.COM
Business Contact:
MANAK
(301) 208-8100
MMANAK@BBII.COM
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): This proposal describes the feasibility study of using Boston Biomedica, Inc.'s proprietary Pressure Cycling Technology (PCT), its instrument (Barocylcer) and its novel sample preparation tube (PULSE) to process sputum and Mycobacteria species for detection by current laboratory methods. Current sample processing methods are flawed because not only do they reduce the rapid growing native flora but also inactivate most of the viable Mtb, which significantly reduces the sensitivity of growth-based detection methods. Current sample processing methods also require several manipulations by the laboratory worker, which increases their likelihood of exposure to infection through the production of aerosols. If successful, the development of this novel sample processing method will lead to better patient management for tuberculosis by increasing sensitivity leading to earlier detection of the disease. Although beyond the scope of this study, this system may be ultimately combined into an integrated sample preparation procedure and detection system, which is amenable to a high throughput automated format.

* information listed above is at the time of submission.

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