OPTICAL ASSAYS FOR MICROBIAL INFECTIONS

Award Information
Agency: Department of Defense
Branch: Army
Contract: N/A
Agency Tracking Number: 8377
Amount: $47,800.00
Phase: Phase I
Program: SBIR
Awards Year: 1988
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
5766 Central Ave, Boulder, CO, 80301
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 DR DIANA M MAUL
 (303) 447-1605
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE DIFFICULTY IN DIAGNOSIS OF MICROBIAL INFECTIONS IS DUE TO THE WIDE VARIETY OF MICRO-ORGANISMS WHICH INFECT MAN, AND TO THE VARIATION IN HOST RESPONSE TO SUCH INFECTIONS. IN CASES WHERE ANTIBODIES ARE RAPIDLY PRODUCED AND SUSTAINED FOR A LONG PERIOD OF TIME, DIAGNOSIS BASED ON THESE ANTIBODIES IS USEFUL. HOWEVER, LEVELS OF ANTIBODY MAY VARY DRASTICALLY BETWEEN INDIVIDUALS AND MAY BE PRESENT IN THE ABSENCE OF CLINICAL SYMPTONS. FOR ABSOLUTE IDENTIFICATION OF A MICROBIAL INFECTION, THE ABILITY TO DETECT THE PRESENCE OF SPECIFIC GENES USING DNA PROBES IS A VERY ATTRACTIVE TECHNIQUE BUT THE CURRENT TECHNOLOGY IS NOT READILY ADAPTED TO FIELD USE. BIO-STAR HAS A UNIQUE OPTICAL ASSAY FORMAT THAT LENDS ITSELF TO THE DETECTION OF ANTIBODIES PRODUCED TO MICRO-ORGANISMS, TO THE DETECTION OF MICROBIAL ANTIGENS, OR THE DETECTION OF THE MICRO-ORGANISMS GENETIC MATERIAL. THE OPTICAL FORMAT EXISTS IN TWO SEPARATE TYPES: 1) A HIGHLY QUANTITATIVE FORMAT AND 2) A QUALITATIVE OT A SEMI-QUANTITATIVE FORMAT. THIS ASSAY'S FLEXIBILITY ALLOWS DIAGNOSIS OF ANTIBODIES, ANTIGENS AND GENETIC MATERIAL BASED ON MULTIPLE LIGAND/ANALYTE COMBINATIONS WHICH ARE EASILY USABLE IN FIELD TESTING.

* Information listed above is at the time of submission. *

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