SIMULTANEOUS DETECTION OF MULTIPLE DISEASE STATES

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$49,657.00
Award Year:
1989
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
9507
Agency Tracking Number:
9507
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
5766 Central Ave, Boulder, CO, 80301
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr Luis Lopez
(303) 447-1605
Business Contact:
() -
Research Institute:
n/a
Abstract
BIO-STAR PROPOSES TO DEVELOP A SOLID PHASE ASSAY FOR THE SIMULTANEOUS DETECTION OF THREE OR MORE ANALYTES (ANTIGENS AND/OR ANTIBODIES), USING AN OPTICAL INTERFERENCE SIGNAL. THIS OPTICAL IMMUNOASSAY (OIA) IS A TECHNIQUE FOR THE DIRECT PHYSICAL DETECTION OF THE IMMUNOCHEMICAL REACTION AND GENERALLY DOES NOT REQUIRE THE USE OF ANY ADDED REAGENTS. THE SIGNAL CAN BE DETECTED WITH THE UNAIDED EYE, OR WITH A REFLECTOMETER OR ELLIPSOMETER FOR QUANTIFICATION. EACH ASSAY WILL BE CONDUCTED ON A DISTINCT REACTION ZONE ON THE SLIDE. WE PROPOSE TO CONVERT THREE ELISA TESTS INTO THE OIA FORMAT DURING PHASE I. THESE TESTS DETECT THE PRESENCE OF ANTIBODIES ASSOCIATED WITH AUTOIMMUNE DISEASES. WE WILL DEMONSTRATE THE ABILITY TO IMMOBILIZE THREE DISTINCT CLASSES OF MOLECULES ON OUR SUBSTRATE, AND TO GENERATE A DETECTABLE SIGNAL WITH OIA. IN PHASE II WE WILL BUILD THE FINAL TRI-ANALYTE PROTOTYPE, THEN USE THIS ASSAY DEVELOPMENT EXPERIENCE TO DESIGN A TRI-ANALYTE TEST FOR THREE DISEASES OF MILITARY SIGNIFICANCE.THE FINAL TEST WILL BE SENSITIVE, RAPID, AND SUITABLE FOR USE IN BOTH LABORATORY AND FIELD ENVIRONMENTS. THE FLEXIBILITY AND SIMPLICITY OF THE OIA FORMAT MAKES THIS TECHNOLOGY IDEALLY SUITED TO THE DEVELOPMENT OF TRI-ANALYTE IMMUNOASSAYS.

* information listed above is at the time of submission.

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