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FGF-SILYL-HEPARIN CEREBRAL ANEURYSM COILS

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43NS043809-01
Agency Tracking Number: NS043809
Amount: $105,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2002
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
BIOSURFACE ENGR TECHNOLOGIES 387 TECHNOLOGY DR
COLLEGE PARK, MD 20742
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 PAUL ZAMORA
 (301) 405-8533
 PZAMORA@BIOSETINC.COM
Business Contact
 THOMAS ROUECHE
Phone: (301) 405-8263
Research Institution
N/A
Abstract

DESCRIPTION (provided by applicant): Cerebral aneurysms can be life threatening
and because the blood vessel is weak they are subject to rupture. Platinum
coils are currently used as an experimental treatment for inoperable cerebral
aneurysms and function by inducing thrombosis within the aneurysm. The
metal/thrombus fills the aneurysm, thereby restoring a more normal blood flow
in the blood vessel. Currently used coils do not stimulate tissue in-growth
into the aneurysm or blood vessel wall, thereby leaving the vessel wall
weakened and with a continued susceptibility to rupture. We propose improving
aneurysm coils by coating a modified, proprietary heparin onto the surface, and
then using the affinity of hepann to further complex basic fibroblast growth
factor (FGF-2). The coating is simple and cost-effective as it is performed
using adsorption and affinity techniques. The FGF will encourage local cell
migration and proliferation resulting in a strengthening of the aneurysm wall
and a filling of the aneurysm with cellular material. Our initial studies
suggest that the heparin can be modified to alter the rate of release from a
substrate, a factor that could help control the bioavailability in vivo. The
Phase I studies will develop the coated coils and perform initial animal
evaluations.

* Information listed above is at the time of submission. *

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