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Radioprotective mimetics of fibroblast growth factors

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43CA103193-01
Agency Tracking Number: CA103193
Amount: $99,750.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2003
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
387 TECHNOLOGY DRIVE SUITE 3119
COLLEGE PARK, MD 20742
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 PAUL ZAMORA
 (301) 405-8533
 PZAMORA@BIOSETINC.COM
Business Contact
 THOMAS ROUECHE
Phone: (301) 405-8431
Email: TROUECHE@BIOSETINC.COM
Research Institution
N/A
Abstract

DESCRIPTION (provided by applicant): We propose to develop and evaluate peptide mimetics of growth factors within the fibrobtast growth factor family. We have designed and produced the first ever synthetic multi-domain peptides, F2A3 and F2A4, that mimic natural FGF-2 and stimulate the biological activity of the FGF receptor. We will expand on this to build peptide mimetics of FGF-1 and FGF-7. The new variants will be evaluated and compared to their recombinant FGF counterparts as well as our current FGF-2 mimetics in a variety of biochemical and cellular assays.

* Information listed above is at the time of submission. *

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