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Microlayered Erythropoietin Implants

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43HL072701-01A1
Agency Tracking Number: HL072701
Amount: $99,975.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 2003
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
WOBURN, MA 01801
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (781) 938-0938
Business Contact
Phone: (781) 938-0938
Research Institution

DESCRIPTION (provided by applicant): BIOTEK has discovered a unique processing method for the efficient and safe formulation of peptides or proteins in polylactide-co-glycolide (PLGA) polymer for long-term implantable delivery. The process is very mild, it gives high yield, and residual organic solvent content is very low. BIOTEK has found that certain combinations of solvent and non-solvent liquids can be used to facilitate blending and microlayered implant filling of drug and PLGA particles without the use of heat or high shear in a way never before possible. This mild processing will be especially valuable in formulations containing peptides and proteins. Also, the process has a very high yield, an important factor when the drugs of interest are costly. The development of this method would offer safe and more economical production of therapeutic protein and peptide products. BIOTEK proposes to apply this microlayered implant technology to the development of a long-lasting delivery formulation of the protein erythropoietin. The BIOTEK technology may also be applicable to other therapeutic proteins

* Information listed above is at the time of submission. *

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