Sensors for Detection of Excessive Alcohol Consumption
Department of Health and Human Services
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Small Business Information
Bio-tek Instruments, Inc.
P. O. Box 998, Highland Park, Winooski, VT, 05404
Socially and Economically Disadvantaged:
Paul D. Hale
AbstractThe goals of the Phase I research period are to construct and test new amperometric biosensors for the determination of several serum enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT), which are frequently associated with alcohol-related organ damage and alcoholism. The sensors are based on the selective detection of products formed by reactions which are catalyzed by these serum enzymes. A novel sensor design permits efficient operation where interference due to dissolved oxygen and spurious current measurements caused by common interference (e. g., ascorbate, urate) are minimized. During Phase II, this technology will be extended to the selective detection of other laboratory markers of alcoholism, such as creatinine, urea, and glutamate dehydrogenase. The optimized sensors could serve an important role in the daily clinical practice of differential diagnostics of alcohol-related organ damage and in follow-up studies of alcoholism treatment programs.
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