Sensors for Detection of Excessive Alcohol Consumption

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$492,254.00
Award Year:
1995
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
22422
Agency Tracking Number:
22422
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
P. O. Box 998, Highland Park, Winooski, VT, 05404
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Paul D. Hale
(802) 655-4040
Business Contact:
() -
Research Institute:
n/a
Abstract
The goals of the Phase I research period are to construct and test new amperometric biosensors for the determination of several serum enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT), which are frequently associated with alcohol-related organ damage and alcoholism. The sensors are based on the selective detection of products formed by reactions which are catalyzed by these serum enzymes. A novel sensor design permits efficient operation where interference due to dissolved oxygen and spurious current measurements caused by common interference (e. g., ascorbate, urate) are minimized. During Phase II, this technology will be extended to the selective detection of other laboratory markers of alcoholism, such as creatinine, urea, and glutamate dehydrogenase. The optimized sensors could serve an important role in the daily clinical practice of differential diagnostics of alcohol-related organ damage and in follow-up studies of alcoholism treatment programs.

* information listed above is at the time of submission.

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