RAPID FIBRINOGEN ASSAY FOR USE IN THROMBOLYTIC THERAPY

Award Information
Agency:
Department of Health and Human Services
Branch:
N/A
Amount:
$500,000.00
Award Year:
1992
Program:
SBIR
Phase:
Phase II
Contract:
N/A
Agency Tracking Number:
13925
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Biotherm Inc.
Po Box 13417, Res Triangle Park, NC, 27709
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
N/A
Principal Investigator
 Bruce J Oberhardt
 (919) 544-2952
Business Contact
Phone: () -
Research Institution
N/A
Abstract
AN ASSAY SYSTEM FOR MONITORING FUNCTIONAL FIBRINOGEN IN PATIENTS UNDERGOING THROMBOLYTIC THERAPY WILL BE DEVELOPED. THIS SYSTEM WILL BE BASED ON A NOVEL DRY REAGENT ASSAY TECHNOLOGY THAT HAS RECENTLY BEEN APPLIED SUCCESSFULLY TO PTAND ACTIVATED PTT TESTS. INTRODUCTION OF A RAPID, CONVENIENT, FIBRINOGEN ASSAY SYSTEM ON A DECENTRALIZED BASISCOULD PROVIDE ACCURATE RESULTS SOONER THAN EXISTING LABORATORY METHODS AND COULD SERVE AS AN IMPORTANT DIAGNOSTIC GUIDE IN THROMBOLYTIC THERAPY. THIS PROJECT WILL DEVELOP THIS FIBRINOGEN ASSAY SYSTEM AND ASSESS ITS POTENTIAL, USING A COMBINATION OF LABORATORY STUDIES OF INFLUENCING FACTORS AND CLINICAL SAMPLE STUDIES. APPLICATION TO EARLY DETERMINATION OF LOW FIBRINOGEN LEVELS IN THROMBOLYTIC THERAPY PATIENTS WILL BE EXPLORED. THIS WORK WILL BE PERFORMED IN CONJUNCTION WITH DUKE UNIVERSITY MEDICAL CENTER.

* information listed above is at the time of submission.

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