DRUG CHALLENGE ASSAY FOR USE IN THROMBOLYTIC THERAPY

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 16730
Amount: $500,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1993
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
P O Box 13417, Res Triangle Park, NC, 27709
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Oberhardt, Bruce J
 Principal Investigator
 (919) 544-2952
Business Contact
 1 R43 HL47223-01
Phone: () -
Research Institution
N/A
Abstract
A TEST SYSTEM FOR RAPID SCREENING OF PATIENTS PRIOR TO INITIATION OF THROMBOLYTIC THERAPY WILL BE DEVELOPED. THIS SYSTEM WILL BE BASED ON A NOVEL DRY REAGENT ASSAY TECHNOLOGY WHICH RECENTLY HAS BEEN APPLIED SUCCESSFULLY TO PT AND ACTIVATED PTT TESTS. INTRODUCTION OF A RAPID CONVENIENT TEST OF PATIENT (OR CLOT) LYTIC POTENTIAL FOR USE ON A DECENTRALIZED BASIS COULD PROVIDE EARLY INDICATION OF LIKELIHOOD OF SUCCESS WITH STREPTOKINASE SOONER THAN EXISTING LABORATORY METHODS AND COULD SERVE AS AN IMPORTANT DIAGNOSTIC GUIDE IN THROMBOLYTIC THERAPY. WE WILL DEVELOP THIS TEST SYSTEM AND TO ASSESS ITS POTENTIAL USING A COMBINATION OF LABORATORY STUDIES AND CLINICAL SAMPLE STUDIES. APPLICATION TO EARLY DETERMINATION OF CLOT LYSIS RESPONSE IN PATIENTS PRIOR TO THROMBOLYTIC THERAPY WILL BE EXPLORED. THIS WORK WILL BE PERFORMED IN CONJUNCTION WITH INVESTIGATORS AT UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL. PHASE I SUPPORT WOULD FUND ASSAY OPTIMIZATION ACTIVITIES AND CLINICAL SAMPLE FEASIBILITY STUDIES.

* Information listed above is at the time of submission. *

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