Surface-Enhanced Detection of Molecular and Biomolecular Species

Award Information
Agency:
Department of Defense
Branch
Air Force
Amount:
$100,000.00
Award Year:
2005
Program:
STTR
Phase:
Phase I
Contract:
FA9550-05-C-0136
Agency Tracking Number:
F054-025-0178
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Biotools, Inc.
950 North Rand Rd, Suite 123, Wauconda, IL, 60084
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
117950563
Principal Investigator:
Laurence Nafie
Distinguished Professor
(315) 443-5912
lnafie@syr.edu
Business Contact:
Rina Dukor
President and CEO
(847) 487-5500
rkdukor@btools.com
Research Institution:
SYRACUSE UNIV.
Trish Lowney
Department of Chemistry, 1-104 CST
Syracuse, NY, 13244
(315) 443-2882
Nonprofit college or university
Abstract
This Phase I STTR will demonstrate the feasibility of near-infrared (near-IR) excited surface-enhanced Raman optical activity (SEROA) as a sensitive new probe of biological molecules and trace chiral materials. The research will use nanoshells as fabricated and optimized at Rice University as a newly developed, tunable, highly-uniform, SERS substrates for chiral molecules and bio-molecules. The feasibility of SEROA using a standard ChiralRAMAN ROA spectrometer from BioTools, Inc. with 532 nm excitation will be determined using commercially available SERS substrates. The project continues with the assembly and testing of a near-IR 785-nm laser version of the ChiralRAMAN spectrometer. The new 785-nm ROA instrument will then be tested in three ways. 1) Its performance as a near-IR excited Raman spectrometer will be compared to the Raman performance of the 532-nm ChiralRAMAN spectrometer. 2) Its performance will next be compared to the near-IR Raman spectrometer currently operating at Rice University for which SERS measurements with tuned nanoshells have been carried out. 3) Finally, its performance as the world's first near-IR ROA spectrometer will be tested with standard liquid samples of chiral terpene molecules. From these comparisons a quantitative prognosis for developing a near-IR SEROA spectrometer using chiral tuned-nanoshells will be established.

* information listed above is at the time of submission.

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