Surface-Enhanced Detection of Molecular and Biomolecular Species

Award Information
Agency: Department of Defense
Branch: Air Force
Contract: FA9550-05-C-0136
Agency Tracking Number: F054-025-0178
Amount: $100,000.00
Phase: Phase I
Program: STTR
Awards Year: 2005
Solicitation Year: 2005
Solicitation Topic Code: AF05-T025
Solicitation Number: N/A
Small Business Information
BIOTOOLS, INC.
950 North Rand Rd, Suite 123, Wauconda, IL, 60084
DUNS: 117950563
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Laurence Nafie
 Distinguished Professor
 (315) 443-5912
 lnafie@syr.edu
Business Contact
 Rina Dukor
Title: President and CEO
Phone: (847) 487-5500
Email: rkdukor@btools.com
Research Institution
 SYRACUSE UNIV.
 Trish Lowney
 Department of Chemistry, 1-104 CST
Syracuse, NY, 13244
 (315) 443-2882
 Nonprofit college or university
Abstract
This Phase I STTR will demonstrate the feasibility of near-infrared (near-IR) excited surface-enhanced Raman optical activity (SEROA) as a sensitive new probe of biological molecules and trace chiral materials. The research will use nanoshells as fabricated and optimized at Rice University as a newly developed, tunable, highly-uniform, SERS substrates for chiral molecules and bio-molecules. The feasibility of SEROA using a standard ChiralRAMAN ROA spectrometer from BioTools, Inc. with 532 nm excitation will be determined using commercially available SERS substrates. The project continues with the assembly and testing of a near-IR 785-nm laser version of the ChiralRAMAN spectrometer. The new 785-nm ROA instrument will then be tested in three ways. 1) Its performance as a near-IR excited Raman spectrometer will be compared to the Raman performance of the 532-nm ChiralRAMAN spectrometer. 2) Its performance will next be compared to the near-IR Raman spectrometer currently operating at Rice University for which SERS measurements with tuned nanoshells have been carried out. 3) Finally, its performance as the world's first near-IR ROA spectrometer will be tested with standard liquid samples of chiral terpene molecules. From these comparisons a quantitative prognosis for developing a near-IR SEROA spectrometer using chiral tuned-nanoshells will be established.

* information listed above is at the time of submission.

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government