RAPID BIOSENSOR ASSAY OF AIDS VIRUS ANTIBODIES

Award Information
Agency:
Department of Health and Human Services
Branch:
N/A
Amount:
$468,037.00
Award Year:
1990
Program:
SBIR
Phase:
Phase II
Contract:
N/A
Agency Tracking Number:
7848
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Biotronic Systems Corp.
15225 Shady Grove Rd #306, Rockville, MD, 20850
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
N/A
Principal Investigator
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE LONG-TERM OBJECTIVE OF THIS RESEARCH IS TO DEVELOP A RAPID, SPECIFIC, COST-EFFECTIVE TEST FOR HUMAN ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS (HIV) ANTIGENS UTILIZING A NOVEL CAPACITIVE AFFINITY SENSOR TECHNOLOGY. THE SPECIFIC AIMS OF THIS RESEARCH ARE: 1) TO EVALUATE METHODS BY WHICH HIV ANTIGENS FROM VIRAL PROTEINS GP41 AND P24 CAN BE IMMOBILIZED ON THE SURFACE OF THE BIOSENSOR AND 2) TO DETERMINE THE MAGNITUDE AND SPECIFICITY OF THE CAPACITANCE CHANGES WHEN SUCH COATED BIOSENSORS INTERACT WITH MOUSE MONOCLONAL AND HUMAN ANTIBODIES AGAINST HIV ANTIGENS. THIS PROJECT WILL CONTRIBUTE TO TECHNOLOGICAL INNOVATION BY ASSESSING THE POTENTIAL APPLICABILITY OF CAPACITIVE AFFINITYSENSOR TECHNOLOGY TO A MAJOR HUMAN HEALTH PROBLEM: IDENTIFICATION OF THOSE PERSONS WHO HAVE BEEN EXPOSED TO HIV. IF RECENT CDC RECOMMENDATIONS ARE FOLLOWED, PERHAPS ASMANY AS 50 MILLION HIV ANTIBODY TESTS WILL BE PERFORMED IN THE U.S. IN 1987. MAKING THIS TEST MORE RAPID AND COST-EFFECTIVE THROUGH UTILIZATION OF CAPACITIVE AFFINITY SENSOR TECHNOLOGY SHOULD HAVE SUBSTANTIAL COMMERCIAL POTENTIAL, BOTH IN THE U.S. AND IN MANY FOREIGN COUNTRIES.

* information listed above is at the time of submission.

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