Near Infrared Spectral Determination of Human Tissue pH

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$70,000.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
28856
Agency Tracking Number:
28856
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
W226 N555b Eastmound Drive, Waukesha, WI, 53186
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Kenneth J. Schlager
(414) 896-2650
Business Contact:
() -
Research Institute:
n/a
Abstract
A reflectiver near infrared (NIR spectrometer is proposed for the noninvasive measurement of surface and deep tissue pH. Previous experimental studies have demonstrated on a preliminary basis the ability to estimate liquide pH in complex biological matrices based on NIR spectra [Dre 90][Sch 93], and the proposed development program will design, contruct and test an experimental bench NIR pH measurement. Biotronics has also demonstrated on a previous and related Navy-sponsored SBIR program, designated TAMM for Transcutaneous Analyte Measuring Method, tested over 750 patients in Navy and civilian hospitals with a reflective NIR instrument for the measurement of the primary human body electrolytes: sodium, chloride, calcium, potassium and bicarbonate. The physical principle involved in these NIR measurements is the same as for pH - ionic distortions of the primary NIR water spectrum. In fact, pH measurements represent a lesser challenge because of the greater density of the hydrogen ion in human tissue. The bench prototype NIR instrument will be designed to operate in different NIR spectral regions to achieve varying depths of tissue penetration and to explore various spectral regions with a view to future spectral optimization in the Phase II preproduction prototype. The previous successful biotronics TAMM experience with reflective NIR spectrometry and pattern recognition in noninvasive human blood electrolyte measurements bodes well for achieving the objectives of this program. commercialization and military applicatiom of the new NIR pH instrument will follow the same paths now opened as a result of the Navy TAMM SBIR program. Major impacts will be in military combat casualty care and civilian emergency medicine.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government