Hot Flash Research Tool for Broad Population Research Studies

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 2R44EB006013-02A2
Agency Tracking Number: EB006013
Amount: $754,728.00
Phase: Phase II
Program: SBIR
Awards Year: 2010
Solicitation Year: 2010
Solicitation Topic Code: NIBIB
Solicitation Number: PHS2010-2
Small Business Information
DUNS: 927303412
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (763) 463-4814
Business Contact
Phone: (763) 463-4814
Research Institution
DESCRIPTION (provided by applicant): This work is focused on exploring the physiological processes and therapies associated with hot flashes. The project proposes to develop a tool for use by researchers studying hot flashes in broad population research studies. Hot flashes are experienced by approximately 80 percent of American women between the ages of 45 and 54 and are a significant concern during menopause. Typically expressed as a period of intense heat with sweating, flushing and rapid heartbeat, episodes usually last from five to ten minutes, but have been reported to last as long as an hour. These events frequently occur at night, and may be repeated anywhere from a few times per week to dozens of times per day. No longer relegated simply to women reaching the end of their child bearing years, hot flashes now affect breast cancer survivors, women with chemotherapy-induced ovarian failure, oopherectomized women, women being treated for endometriosis or infertility with gonadotropin- releasing hormone (GnRH) agonists such as Lupron, and men with prostate cancer undergoing androgen deprivation therapy (ADT). Hot flashes are often disruptive and unpleasant, with broad overall health consequences affecting work responsibilities, social activities, sleep, etc. The fundamental physiological triggering mechanisms of hot flashes are not well understood although hot flash therapies are an area of active research often including large therapy trials in broad populations. These studies require an objective measure of the hot flash phenomenon that optimally correlates with self-reported diary data, is specific to hot flashes, and is accurate under ambulatory conditions. PUBLIC HEALTH RELEVANCE: The proposed project develops technology for researchers studying hot flashes in men and women.

* Information listed above is at the time of submission. *

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