LONG ACTING GH FOR SHORT STATURE AND CACHEXIA

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: DK54079-01
Agency Tracking Number: 39157
Amount: $90,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1997
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
678 W WILLOW ST, Louisville, CO, 80027
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 COX, GEORGE N
 () -
Business Contact
Phone: (303) 665-6530
Research Institution
N/A
Abstract
Growth hormone (GH) is a pituitary derived protein that stimulates somatic growth and other anabolic processes. Recombinant human OH is used to stimulate linear growth in children and to treat cachexia in AIDS patients. The protein must be injected daily for maximum effectiveness. We propose to create modified OH proteins that are equal or superior to natural OH in stimulating anabolic processes in vivo but which require less frequent dosing, on the order of once per week or once every other week. During Phase l we will identity sites in OH that can be modified without affecting the protein's in vitro bioactivity. During Phase II, we will manufacture sufficient quantities of the modified GH proteins for testing in animal models of OH deficiency and cachexia. The improved in vivo characteristics of the novel OH proteins will reduce the amount of OH required per patient, improve patient quality of life and result in considerable cost savings to patients and healthcare providers. OH is a prototype for a large family of structurally related cytokines and growth factors. Results obtained from these studies will be valuable for creating long-acting versions of other members of the OH supergene family for use in treating cancer, infectious diseases and hematopoietic disorders. $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 283 --PROJECT NUMBER......1 R43 DK54172-01 INVESTIGATOR NAME/ADDRESS FY 97 KAPUT, JAMES A IRG/INTRAMURAL UNIT..ZRG2 GENE QUEST INC AWARD AMOUNT......... $99,250 300 EAST SUPERIOR ST CHICAGO, IL 60611-3008 PERFORMING ORGANIZATION: GENE QUEST, INC. TITLE AUTOMATING ANALYSES OF DIET AND GENOTYPE SPECIFIC TESTS ABSTRACT: DESCRIPTION: The human genome project (HGP) is developing databases of DNA sequences and gene maps that are expected to enhance the molecular understanding of normal physiological processes and disease pathology. Most biological processes, especially chronic diseases such as cancer, osteoporosis, and autoimmune diseases, arise from multiple interactions of genes with external factors including dietary constituents. Analyzing and understanding genotype x environment interactions has been difficult because of the complexity of factors and the complexity of the biological responses, which are unique to each individual. The approach proposed by the applicant combines an integrated biological system with an integrated technological system for examining complex genome-based responses in a defined murine model system. The working hypothesis underlying the biological strategy is that a subset of diet- regulated genes participate in disease processes in susceptible individuals. The integrated technological approach is based upon high throughput isolation, identification, and characterization of multiple genes using a novel, fluorescence-based capillary electrophoresis system. The long term goal is to identify and characterize genes regulated by diet and involved in disease processes in model systems in order to develop greater molecular understanding of nutrient- genotype interactions underlying human disease processes. $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 284 --PROJECT NUMBER......1 R43 ES08046-01A1 INVESTIGATOR NAME/ADDRESS FY 97 KRETZ, KEITH A IRG/INTRAMURAL UNIT..ZRG3 RECOMBINANT BIOCATALYSIS INC AWARD AMOUNT......... $95,724 505 COAST BLVD SOUTH LA JOLLA, CA 92037 PERFORMING ORGANIZATION: DIVERSA CORPORATION TITLE HIGHLY DIVERSE, NORMALIZED ENVIRONMENTAL DNA LIBRARIES ABSTRACT: DESCRIPTION (Adapted from applicant's abstract): There has been increasing demand in the research reagent, diagnostic reagent, and chemical process industries for protein-based catalysts possessing novel capabilities. At present, this need is largely addressed using enzymes purified from a variety of cultivated microorganisms, generally members of the domains Bacteria and Archaea. However, because less than 1% of naturally occurring microorganisms have been grown in culture, alternative techniques must be developed to exploit the full-breadth of diversity for potentially valuable new products. We propose to develop a novel recombinant approach to generate and screen DNA libraries constructed from uncultured, mixed microbial populations. Because microorganisms can differ vastly in abundance in natural populations, a normalization strategy will be implemented. We predict that these normalized libraries will allow for greater screening efficiency and will result in the isolation of genes encoding novel biological catalysts. $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 285 --PROJECT NUMBER......1 R43 ES08459-01 INVESTIGATOR NAME/ADDRESS FY 97 ABDELBARR, MOHAMED I IRG/INTRAMURAL UNIT..ZRG1 NUTRACEUTICAL BIOSCIENCES INC AWARD AMOUNT......... $98,700 704 DEMOTT COURT WESTBURY, NY 11590 PERFORMING ORGANIZATION: NUTRACEUTICAL BIOSCIENCES, INC. TITLE ETHANE EXHALATION AS AN INDEX OF NEUROLOGICAL STRESS ABSTRACT: DESCRIPTION (Adapted from Investigator's Abstract): The importance of anti-oxidant defenses in the maintenance of general well-being and optimal health is becoming increasingly recognized both among health specialists and also among the general public. Furthermore, elevated levels of free radical generation and consequent oxidative damage to macromolecules, have been implicated in an increasing number of progressive neurological disoders such as Alzheimer's disease (AD), Parkinsons disease (PD), amyotrophic lateral sclerosis, multiple sclerosis and epilepsy. Antioxidant therapy is being tested experimentally for all the above diseases. Antioxidant utilization has also been proposed as a possible means of reducing the very high incidence of colon cancer in the United States. The use of antioxidants may be of especial value to certain high risk segments of the population such as smokers. Taken together, these issues suggest that this is an appropriate time to promote the development of a convenient means of quantitating the parameter of total bodily oxidant status. This application plans to develop an inexpensive, portable, compact and easily usable chromatographic kit to allow a rapid and accurate quantitative analysis of expired ethane. The measurement of exhaled hydrocarbon gases constitutes a totally non-invasive means of estimating oxidative stress in living organisims.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government