NOVEL BASE BORONATED OLIGONUCLEOTIDES FOR BORON NEUTRON CAPTURE THERAPY

Award Information
Agency:
Department of Energy
Branch
n/a
Amount:
$499,885.00
Award Year:
1990
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
10814
Agency Tracking Number:
10814
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2811 O'berry St, Raleigh, NC, 27607
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr Bernard F Spielvogel
Principal Investigator
(919) 832-2044
Business Contact:
() -
Research Institute:
n/a
Abstract
BORON NEUTRON CAPTURE THERAPY (BNCT) HAS A CLEAR THEORETICALADVANTAGE OVER OTHER TECHNIQUES AS A METHOD OF DELIVERING CELL KILLING RADIATION TO TUMORS. NEW BORON COMPOUNDS ARE NEEDED THAT CAN SELECTIVELY LOCALIZE IN TUMORS AND, UPON CAPTURE OF THERMAL OR EPITHERMAL NEUTRONS, PRODUCE RADIATIONTO KILL TUMOR CELLS BUT SPARE NORMAL TISSUE AND BLOOD. BNCTEFFECTIVENESS WOULD BE GREATEST IF THE BORON TARGETED THE CELL NUCLEUS AND LOWER CONCENTRATIONS COULD BE USED. PHASE I WILL SYNTHESIZE BORONATED OLIGONUCLEOTIDES THAT ARE RESISTANT TO NUCLEASES AND THAT SHOULD READILY ENTER CELLS AND TARGET (BY AN "ANTISENSE" MECHANISM) THE DNA OR RNA NUCLEAR MATERIAL OF TUMOR CELLS. THE OLIGONUCLEOTIDES WILL BE PREPARED BOTH CHEMICALLY AND ENZYMATICALLY USING NUCLEOSIDES THAT HAVE BEEN BORONATED ON BASE POSITIONS, AFFECTING BASE PAIRING ABILITIES AND OTHER NORMAL ACTIVITY ONLY MINIMALLY (IF AT ALL). OF CONSIDERABLE ADDED VALUE IS THE EXPECTED ANTI-TUMOR ACTIVITY OF THE BORONATED OLIGONUCLEOTIDES IN ADDITION TO THAT PROVIDED BY BNCT.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government