NEW GADOLINIUM-BORON COMPOUNDS FOR NEUTRON CAPTURE THERAPY

Award Information
Agency: Department of Energy
Branch: N/A
Contract: N/A
Agency Tracking Number: 17502
Amount: $500,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1993
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
533 Pylon Dr, Raleigh, NC, 27606
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Dr. Bernard F. Spielvogel
 () -
Business Contact
 Mr. Todd Bishop
Phone: (919) 832-2044
Research Institution
N/A
Abstract
NEUTRON CAPTURE THERAPY IS A VERY PROMISING THERAPY FOR CERTAIN TUMORS, SUCH AS GLIOMAS AND MELANOMAS. SEVERAL NUCLEI HAVE HIGH CROSS SECTIONS FOR THERMAL NEUTRONS, OF WHICH BORON-10 ((10)B) AND GADOLINIUM-157 ((157)GD) HAVE BEEN SHOWN TO BE VERY PROMISING. (10)B HAS A HIGH CROSS SECTION FOR THERMAL NEUTRONS AND A VERY VERSATILE CHEMISTRY. (157)GD HAS THE HIGHEST CROSS SECTION FOR THERMAL NEUTRONS AND, BEING PARAMAGNETIC, IS GOOD FOR MAGNETIC RESONANCE IMAGING. A COMBINATION OF THESE TWO NUCLEI IN A SINGLE ENTITY SHOULD PROVIDE A SINGLE, MORE CONVENIENT WAY TO DIAGNOSE AND TREAT TUMORS. PHASE I RESEARCH FOCUSES ON THE SYNTHESIS OF A MOLECULE CONTAINING BOTH (10)B AND (157)GD AND ON EVALUATING ITS STABILITY, TOXICITY (LD50), AND IN-VITRO EFFICACY. PHASE II RESEARCH WILL BE CONCERNED WITH THE EVALUATION OF IN-VIVO EFFICACY, STRUCTURE-ACTIVITY RELATIONSHIP STUDIES TO OPTIMIZE EFFICACY AND DETERMINE THE PHARMACOKINETICS, TISSUE DISTRIBUTION, AND TOXICITY (SAFETY) OF LEAD COMPOUND(S).

* Information listed above is at the time of submission. *

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