THE GOAL IS TO DEVELOP AND APPLY METHODS SUITABLE FOR PREPARING COMMERCIALLY VALUABLE HUMAN MONOCLONAL ANTIBODIES.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$59,896.00
Award Year:
1983
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
510
Agency Tracking Number:
510
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
10 Broad Way, P.o. Box 234, Hawthorne, NY, 10532
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
WOLD PRENSKY
PRINCIPAL INVESTIGATOR
(914) 747-1522
Business Contact:
() -
Research Institution:
n/a
Abstract
THE GOAL IS TO DEVELOP AND APPLY METHODS SUITABLE FOR PREPARING COMMERCIALLY VALUABLE HUMAN MONOCLONAL ANTIBODIES.IN PHASE I THIS GOAL WILL BE APPROACHED BY THE DEVELOPMENT OF AN EFFECTIVE SYSTEM FOR "IMMORTALIZING" ANTIBODY SECRETING LYMPHOCYTES. SPECIFICALLY, THE APPLICANT WILL TRANSFECT HUMAN B CELLS WITH TRANSFORMING DNA, OBTAINED FROMDIFFERENT TYPES OF TUMOR CELLS, AND DETERMINE THE FREQUENCY OF TRANSFORMANTS WHICH SECRETE ANTIBODY AND GROW IN TISSUE CULTURE. THE YIELD OF SUCH TRANSFORMANTS WILL BE COMPARED TO THAT OF HUMAN ANTIBODY SECRETING HYBRIDOMAS OBTAINED FROM CELL FUSION EXPERIMENTS USING THIOGUANINE-RESISTANT GM1500 CELLS. THE METHOD FOUND TO BE MOST EFFECTIVE WILL BE USED FOR PREPARING CELL CLONES SECRETING ANTIBODIES TO SPECIFIC ANTIGENS SUCH AS ENTEROTOXIN B, CYTOMEGALOVIRUS, AND OTHER VIRAL OR BACTERIAL ANTIGENS DEEMED TO BE OF CLINICAL IMPORTANCE. ADVANTAGE WILL BE TAKEN OF BIOLOGICAL RESPONSE MODIFIERS, SOME DERIVED FROM T CELL HYBRIDOMAS, AS WELL AS OF TECHNIQUES OF "IN VITRO" SENSITIZATION, TO INCREASE THE POOL OF DESIRABLE ANTIBODY SECRETING CELLS OBTAINED FROM HUMAN PERIPHERAL BLOOD.

* information listed above is at the time of submission.

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