THE FABRICATION OF MULTIELECTRODES FOR CHRONIC, SIMULTANEOUS RECORDING OF SINGLE NEURONS IN TISSUE CULTURES, PERIPHERAL NERVES, HIPPOCAMPUS, AND CEREBRAL CORTEX HAS PROGRESSED TO THE POINT WHERE THE VOLUME OF SINGLE-UNIT DATA IS NOW SIGNIFICANT.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 3311
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1985
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Business & Technological Syste
10210 Greenbelt Road, Seabrook, MD, 20706
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 MITCHELL R. BELZER
 PRINCIPAL INVESTIGATOR
 (301) 794-8800
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE FABRICATION OF MULTIELECTRODES FOR CHRONIC, SIMULTANEOUS RECORDING OF SINGLE NEURONS IN TISSUE CULTURES, PERIPHERAL NERVES, HIPPOCAMPUS, AND CEREBRAL CORTEX HAS PROGRESSED TO THE POINT WHERE THE VOLUME OF SINGLE-UNIT DATA IS NOW SIGNIFICANT. RECENT ADVANCES IN SIGNAL PROCESSING ARE BEING USED BY BTS TO DEVELOP IMPROVED METHODS OF EXTRACTING SINGLE-UNIT ACTIVITY. ADVANCES IN AREAS SUCH AS FEATURE EXTRACTION, ADAPTIVE FILTERING, CLUSTER ANALYSIS, AND SPIKE SORTING WITH AUTOMATIC TRACKING THE RESULT EXPECTED FROM OUR PHASE I EFFORTS WILL BE A NUMBER OF FEASIBLE DESIGNS FOR A MULTICHANNEL SPIKE SORTER THAT IS ABLE TO ADAPT TO TIME-VARYING SPIKE WAVEFORM PARAMETERS. INITIAL PHASE II EFFORTS WILL BE TO SELECT THE BEST DESIGN VIA COMPUTER MODELING OF THE DETECTION AND CLASSIFICATION ALGORITHMS FROM PHASE I RESEARCH. A HARDWARE PROTOTYPE WILL THEN BE BUILT AND TESTED USING REAL DATA.

* information listed above is at the time of submission.

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