You are here

Mycotoxin Adsorption with Hemocompatible Porous Polymer Beads

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911QY-16-P-0048
Agency Tracking Number: C152-003-0046
Amount: $149,935.98
Phase: Phase I
Program: SBIR
Solicitation Topic Code: CBD152-003
Solicitation Number: 2015.2
Solicitation Year: 2015
Award Year: 2016
Award Start Date (Proposal Award Date): 2015-12-22
Award End Date (Contract End Date): 2016-05-02
Small Business Information
7 Deer Park Drive, Suite K
Monmouth Junction, NJ 08852
United States
DUNS: 830014077
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Phillip P Chan, MD, PhD
 (732) 329-8885
Business Contact
 James Cason
Phone: (732) 329-8885
Research Institution

Acute exposure to mycotoxins can lead to systemic toxicity and even death. With no specific treatment available, aflatoxin and trichothecene T-2toxin, in particular, are of concern as potential biological weapons due to their toxicity, thermal and UV stability and easy accessibility. As amedical countermeasure, we propose the development of highly porous polymer beads optimized for removal of aflatoxin and T-2 toxin, based ona proven pore capture and surface adsorption technology platform. Previous work has demonstrated significant removal of aflatoxin from wholeblood in vitro. We hypothesize removal of >90% of toxin levels in circulation by hemoperfusion will have a significant clinical impact on recoveryfrom exposure. In the current submission, we will demonstrate >90% removal of T-2 toxin from blood in vitro in a BSL-3 facility and identify theminimal polymer dosage required to achieve >90% removal of aflatoxin and T2 toxin. In anticipation of Phase II studies, an animal model andtesting facility will be selected and specific protocols submitted for IACUC approval. The outcome will be the demonstration of a safe and effectivemethod for removal of aflatoxin and T-2 toxin from blood, a currently unaddressed area of relevance for biological warfare defense.

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government