Exploiting Natural Products-Based Therapeutics for Aflatoxin Mitigation

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911QY-16-P-0049
Agency Tracking Number: C152-003-0072
Amount: $149,956.42
Phase: Phase I
Program: SBIR
Solicitation Topic Code: CBD152-003
Solicitation Number: 2015.2
Timeline
Solicitation Year: 2015
Award Year: 2016
Award Start Date (Proposal Award Date): 2015-12-22
Award End Date (Contract End Date): 2016-05-02
Small Business Information
701 McMillian Way NW, Suite D, Huntsville, AL, 35806
DUNS: 185169620
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Dr. Narender Singh
 (256) 726-4800
 proposals-contracts@cfdrc.com
Business Contact
 Mrs. Deb Phipps
Phone: (256) 726-4884
Email: deb.phipps@cfdrc.com
Research Institution
N/A
Abstract
Aflatoxins are a paradigm among fungal produced mycotoxins that are present in food supplies and are strongly associated with increased risk forthe development of hepatocellular carcinoma. Currently, there are no known countermeasures that can selectively mitigate aflatoxin toxicity andthe available options are only symptomatic treatments. To meet this challenge, we propose to harness the microbiome of scavenging mammalianspecies for bioactive natural products that can potentially be developed as aflatoxin countermeasures. We will couple the identified bioactivenatural products from the microbiome with omics-based approaches to further identify the known and unknown aflatoxin drug targets andpathways. Ultimately, this information will be used to screen databases of approved drugs and clinical trial candidates to discover their repurposedrole as aflatoxin countermeasures. The final outcome of this project will provide 1) novel, potent and safe natural product-based lead structures,and 2) a platform to repurpose known drugs for providing rapid transition from bench to bedside for aflatoxin countermeasures. This projectrepresents a compelling opportunity to prevent the threat associated with aflatoxin induced toxicity that will benefit both public and military health.

* Information listed above is at the time of submission. *

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