High-throughput Direct Structural Screening for Drug Lead Compounds

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$100,000.00
Award Year:
2006
Program:
STTR
Phase:
Phase I
Contract:
W81XWH-06-C-0403
Award Id:
77837
Agency Tracking Number:
A064-032-0110
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
3491 Trinity Drive, Suite B, Los Alamos, NM, 87544
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
147452275
Principal Investigator:
BenjaminWarner
(505) 412-2345
warner@caldera-pharmaceuticals.com
Business Contact:
BenjaminWarner
CEO
(505) 412-2345
warner@caldera-pharmaceuticals.com
Research Institute:
LOS ALAMOS NATIONAL LABORATORY
Christy Ruggiero
Mail Stop J514
Los Alamos, NM, 87545
(505) 667-8457
Federally funded R&D center (FFRDC)
Abstract
U.S. Government personnel deployed in tropical and neotropical regions continue to be at risk for developing malaria. Drug resistant malaria parasites are becoming more common in these areas, increasing the risk of American personnel developing a serious, life-threatening disease. Cross resistance between drugs is becoming much more common. Due to the emergence of drug resistance, derivates of known anti-malarial drug classes are not long term solutions. Faced with the realities of the malaria threat, novel, unbiased technologies are required to prime the drug discovery programs. High-throughput techniques for lead compound generation are well known, but these techniques tend to be too expensive for use on tropical diseases, which do not affect rich populations. New techniques to bring down the costs are required. A method for measuring small molecules and molecule fragments will make tropical disease cures more affordable, and therefore allow the possibility of cures. This project will demonstrate the ability to of X-ray techniques to detect the interactions of cycloguanil, a known dihydrofolate reductase inhibitor, with wild-type and quadruple mutant P. falciparium DHFR-TS. This project will demonstrate automated x-ray data collection and processing to demonstrate the complete direct screening technology package.

* information listed above is at the time of submission.

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