Generation of Peptide-Based Ligands for Chemical and Biological Agent Identification

Award Information
Agency:
Department of Defense
Branch
Air Force
Amount:
$100,000.00
Award Year:
2007
Program:
SBIR
Phase:
Phase I
Contract:
FA8650-07-M-5410
Agency Tracking Number:
F071-132-0039
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
CALDERA PHARMACEUTICALS, INC.
3491 Trinity Drive, Suite B, Los Alamos, NM, 87544
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
147452275
Principal Investigator:
Eva Birnbaum
CSO
(505) 661-2420
eva@cpsci.com
Business Contact:
Benjamin Warner
CEO
(505) 412-2345
warner@cpsci.com
Research Institution:
n/a
Abstract
Caldera will use its R&D 100 award-winning Reagentless Pharmacoproteomic Measurement (RPM) technology to develop chemical/biological (C/B) agent taggants for incorporation into a portable read-out device. RPM technology was developed at Los Alamos National Laboratory and licensed to Caldera. We propose: (1) to generate selective peptide-based capture agent molecules which form highly specific complexes with C/B agents, thereby eliminating the false positive problems that plague current sensors, (2) to develop the ability to "report" binding events, and (3) to produce a prototype sensor device. RPM offers direct chemical measurement of analyte-ligand binding affinity and analyte-ligand selectivity. Caldera will incorporate reporter functional groups into these ligands, to provide for optical reading of C/B agent presence and concentration. We offer a highly novel approach for the generation of non-antibody, peptide-based capture agents, performed by a team with proven expertise in developing label-free reporter methodologies and C/B sensors. RPM technology is extremely rapid and adaptable, which are both attributes necessary due the ever-changing threat situation.

* information listed above is at the time of submission.

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