Generation of Peptide-Based Ligands for Chemical and Biological Agent Identification

Award Information
Agency:
Department of Defense
Branch
Air Force
Amount:
$100,000.00
Award Year:
2007
Program:
SBIR
Phase:
Phase I
Contract:
FA8650-07-M-5410
Award Id:
82063
Agency Tracking Number:
F071-132-0039
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
3491 Trinity Drive, Suite B, Los Alamos, NM, 87544
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
147452275
Principal Investigator:
Eva Birnbaum
CSO
(505) 661-2420
eva@cpsci.com
Business Contact:
Benjamin Warner
CEO
(505) 412-2345
warner@cpsci.com
Research Institution:
n/a
Abstract
Caldera will use its R&D 100 award-winning Reagentless Pharmacoproteomic Measurement (RPM) technology to develop chemical/biological (C/B) agent taggants for incorporation into a portable read-out device. RPM technology was developed at Los Alamos National Laboratory and licensed to Caldera. We propose: (1) to generate selective peptide-based capture agent molecules which form highly specific complexes with C/B agents, thereby eliminating the false positive problems that plague current sensors, (2) to develop the ability to "report" binding events, and (3) to produce a prototype sensor device. RPM offers direct chemical measurement of analyte-ligand binding affinity and analyte-ligand selectivity. Caldera will incorporate reporter functional groups into these ligands, to provide for optical reading of C/B agent presence and concentration. We offer a highly novel approach for the generation of non-antibody, peptide-based capture agents, performed by a team with proven expertise in developing label-free reporter methodologies and C/B sensors. RPM technology is extremely rapid and adaptable, which are both attributes necessary due the ever-changing threat situation.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government