Generation of Peptide-Based Ligands for Chemical and Biological Agent Identification

Award Information
Agency: Department of Defense
Branch: Air Force
Contract: FA8650-07-M-5410
Agency Tracking Number: F071-132-0039
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2007
Solicitation Year: 2007
Solicitation Topic Code: AF071-132
Solicitation Number: 2007.1
Small Business Information
3491 Trinity Drive, Suite B, Los Alamos, NM, 87544
DUNS: 147452275
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Eva Birnbaum
 CSO
 (505) 661-2420
 eva@cpsci.com
Business Contact
 Benjamin Warner
Title: CEO
Phone: (505) 412-2345
Email: warner@cpsci.com
Research Institution
N/A
Abstract
Caldera will use its R&D 100 award-winning Reagentless Pharmacoproteomic Measurement (RPM) technology to develop chemical/biological (C/B) agent taggants for incorporation into a portable read-out device. RPM technology was developed at Los Alamos National Laboratory and licensed to Caldera. We propose: (1) to generate selective peptide-based capture agent molecules which form highly specific complexes with C/B agents, thereby eliminating the false positive problems that plague current sensors, (2) to develop the ability to “report” binding events, and (3) to produce a prototype sensor device. RPM offers direct chemical measurement of analyte-ligand binding affinity and analyte-ligand selectivity. Caldera will incorporate reporter functional groups into these ligands, to provide for optical reading of C/B agent presence and concentration. We offer a highly novel approach for the generation of non-antibody, peptide-based capture agents, performed by a team with proven expertise in developing label-free reporter methodologies and C/B sensors. RPM technology is extremely rapid and adaptable, which are both attributes necessary due the ever-changing threat situation.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government