XRpro Discovery of Decorporation Agents

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43AI079935-01A1
Agency Tracking Number: AI079935
Amount: $600,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2009
Solicitation Year: 2009
Solicitation Topic Code: N/A
Solicitation Number: PHS2009-2
Small Business Information
278 DP Road Suite D, LOS ALAMOS, NM, 87544
DUNS: 147452275
HUBZone Owned: Y
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 BENJAMIN WARNER
 (505) 412-2345
 WARNER@CALDERA-PHARMACEUTICALS.COM
Business Contact
 BENJAMIN WARNER
Phone: (505) 661-2420
Email: court@cpsci.com
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): Caldera Pharmaceuticals will use award-winning XRpro, a high throughput, label-free technology for producing nano-engineered radionuclide decorporation agents that are highly specific for their target radionuclide over similar elements. This proposal displays preliminary results showing specific decorporation agents for Sr(II) that do not bind Ca(II); Sr(II) is the only form of strontium (Sr) that is of concern for decorporation. Decorporation agents specific for elements such as Sr(II) and Co(II), which do not bind any essential metals, including Cu(II), Ca(II), Ni(II), Zn(II) are necessary. Emergency responders are currently forced to use non-selective chelators and blocking agents for radionuclide exposures. Sr-90 is easily obtainable by terrorists who wish to do harm to US citizens, so Sr-90 decorporation is a very high national priority and treatments for Sr-90 exposures remain a critical need for the Strategic National Stockpile. Caldera's specific aims include using highly specific XRpro binding technologies to produce Sr decorporation agents. PUBLIC HEALTH RELEVANCE: Caldera Pharmaceuticals will use award-winning XRpro, a high throughput, label-free technology for producing nano-engineered radionuclide decorporation agents that are highly specific for their target radionuclide over similar elements. Emergency responders are currently forced to use non-selective chelators and blocking agents for radionuclide exposures. Sr-90 is easily obtainable by terrorists who wish to do harm to US citizens, so Sr-90 decorporation is a very high national priority and treatments for Sr-90 exposures remain a critical need for the Strategic National Stockpile.

* Information listed above is at the time of submission. *

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