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High-Throughput Low-Cost Manufacturing of Engineered MRI Contrast Agents

Award Information
Agency: Department of Commerce
Branch: National Institute of Standards and Technology
Contract: 70NANB16H193
Agency Tracking Number: 031.01.03 (2016)
Amount: $298,706.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: 9.01.03
Solicitation Number: N/A
Solicitation Year: 2016
Award Year: 2016
Award Start Date (Proposal Award Date): 2016-08-01
Award End Date (Contract End Date): 2018-07-31
Small Business Information
5611 Roosevelt Street
Bethesda, MD 20817-6739
United States
DUNS: 809594661
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Lamar Mair
 (202) 568-1608
Business Contact
 Irving Weinberg
Phone: (301) 346-7944
Research Institution

New shape-engineered iron-based microscopic contrast agents (MCAs) for magnetic resonance imaging promise to increase diagnostic accuracy while reducing side effects, and enhance scientists’ ability to track stem cells. Currently, techniques used for making multispectral microscale contrast agent particles are cost prohibitive. In Phase I, an innovative technique (employing template-guided electroplating in a roll-to-roll construct) which combines the low cost of chemical synthesis methods, the high uniformity of template-based methods, and the high throughput of automated manufacturing methods to deliver a process for large-scale, cost-effective manufacturing of the new MCAs was described. In Phase II, the Phase I prototype process will be upgraded to include a section that will metallize PCTE reel stock in order to reduce costs, and another section which will measure the NMR resonance shift properties of the particles in situ in order to achieve high particle uniformity. Low-cost production and development of standard operating procedures that will assist in Phase III migration to contract manufacturing facilities will be demonstrated.

* Information listed above is at the time of submission. *

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