THE GOAL OF THE PROPOSED RESEARCH IS TO PRODUCE EFFECTIVE HUMAN PARATHYROID HORMONE (PTH) ANTAGONIST PEPTIDES IN ESCHERICHIA COLI USING STATE-OF-THE-ART RECOMBINANT DNA (RDNA) TECHNOLOGIES.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 3186
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1985
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
California Biotechnology Inc
2450 Bayshore Frontage Road, Mountain View, CA, 94043
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 GEORGE PHILLIP VLASUK
 PRINCIPAL INVESTIGATOR
 (415) 966-1550
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE GOAL OF THE PROPOSED RESEARCH IS TO PRODUCE EFFECTIVE HUMAN PARATHYROID HORMONE (PTH) ANTAGONIST PEPTIDES IN ESCHERICHIA COLI USING STATE-OF-THE-ART RECOMBINANT DNA (RDNA) TECHNOLOGIES. THE CLINICAL UTILITY OF AN EFFECTIVE ANTAGONIST TO PTH ACTION IN VIVO LIES IN THE TREATMENT OF HYPERCALCEMIC DISORDERS INVOLVING THE OVERPRODUCTION OF PTH AND PTH-LIKE COMPOUNDS. THE PRODUCTION OF PTH ANTAGONIST PEPTIDES IN MICROORGANISMS MAY BE MORE ECONOMICALLY FEASIBLE THAN THE CURRENT COSTLY METHOD OF PRODUCTION USING CHEMICAL SYNTHESIS. MORE IMPORTANTLY, IN CONTRAST TO CONVENTIONAL CHEMICAL SYNTHESIS, A VARIETY OF DIFFERENT ANALOGUES CAN BE READILY AND ECONOMICALLY PRODUCED BY SIMPLY ALTERING THE GENE FOR THE ANTAGONIST PEPTIDE USING STANDARD RDNA METHODOLOGIES. THEREFORE THE PROPOSED PHASE I RESEARCH WILL DETERMINE WHETHER A PTH ANTAGONIST PEPTIDE SIMILAR TO THAT DESCRIBED BY ROSENBLATT AND COLLEAGUES (HORIUCHI, N., HOLICK, M.F., POTTS, J.T. AND ROSENBLATT, M. 1983 SCIENCE 220, 10351055) CAN BE PRODUCED IN SIGNIFICANT QUANTITIES AND EFFICIENTLY PURIFIED FOR E. COLI. THIS WORK IS CRITICAL TO THE PHASE II RESEARCH PLAN WHICH WILL REQUIRE SIGNIFICANT QUANTITIES OF PTH

* information listed above is at the time of submission.

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