HYPERTENSION, RESULTING IN SECONDARY ORGAN DAMAGE AND REDUCED LIFE SPAN, IS ONE OF THE MOST IMPORTANT PUBLIC HEALTH PROBLEMS IN DEVELOPED COUNTRIES.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 3223
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1985
Solitcitation Year: N/A
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
California Biotechnology Inc
2450 Bayshore Frontage Rd., Mountain View, CA, 94043
Duns: N/A
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 PHILIPPE M. FROSSARD
 PRINCIPAL INVESTIGATOR
 (415) 966-1550
Business Contact
Phone: () -
Research Institution
N/A
Abstract
HYPERTENSION, RESULTING IN SECONDARY ORGAN DAMAGE AND REDUCED LIFE SPAN, IS ONE OF THE MOST IMPORTANT PUBLIC HEALTH PROBLEMS IN DEVELOPED COUNTRIES. IT IS A MULTIFACTORIAL DISEASE FOR WHICH ETIOLOGY IS UNKNOWN IN 95% OF CASES. THERE IS CURRENTLY NO PREDICTIVE DIAGNOSIS FOR THIS DISEASE. THE LONG-TERM OBJECTIVE OF THE PROJECT DESCRIBED IN THIS PROPOSAL IS THE DEVELOPMENT OF A DIAGNOSTIC TEST FOR THE DETECTION OF AN INDIVIDUAL'S SUSCEPTIBILITY TO HYPERTENSION. THE METHOD WILL BE BASED ON THE ANALYSIS OF RESTRICTION FRAGMENT-LENGTH POLYMORPHISMS WHICH ARE SCATTERED THROUGHOUT THE HUMAN GENOME AND WHICH MAY CORRELATE WITH RISK FACTORS INVOLVED IN THE ONSET OF THE DISEASE. RENIN AND ATRIAL NATRIURETIC FACTOR PLAY A KEY ROLE IN THE REGULATION OF BLOOD PRESSURE. THEREFORE, WE PROPOSE IN PHASE I TO FIND GENETIC MARKERS AT THE RENIN AND ATRIAL NATRIURETIC FACTOR GENE LEVELS AND TO CORRELATE THE PRESENCE OF THESE MARKERS WITH SPECIFIC TYPES OF HYPERTENSION. PHASE II EFFORT WILL EXTEND STUDIES TO THESE AND OTHER GENES INVOLVED IN THE DEVELOPMENT OF HYPERTENSION. LARGER PATIENT POPULATIONS WILL ALSO BE CONSIDERED. THE TEST THAT WE WILL DEVELOP WILL BE COMMERCIALIZED IN THE FORM OF A DIAGNOSTIC KIT TO DETECT INDIVIDUALS AT RISK FOR HYPERTENSION SO THAT TRUE PREVENTION CAN BE PRACTICED.

* information listed above is at the time of submission.

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