THE RECENT DISCOVERY OF ATRIAL NATRIURETIC FACTOR (ANF) PEPTIDES IN MAMMALIAN ATRIA THAT HAVE POTENT NATRIURETIC, DIURETIC AND VASORELAXANT ACTIVITY HAS IMPLICATED THESE SUBSTANCES IN THE CONTROL OF FLUID VOLUME AND BLOOD PRESSURE.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1985
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
3225
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
California Biotechnology Inc
2450 Bayshore Frontage Rd., Mountain View, CA, 94043
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
ROBERT M. SCARBOROUGH
PRINCIPAL INVESTIGATOR
(415) 966-1550
Business Contact:
() -
Research Institution:
n/a
Abstract
THE RECENT DISCOVERY OF ATRIAL NATRIURETIC FACTOR (ANF) PEPTIDES IN MAMMALIAN ATRIA THAT HAVE POTENT NATRIURETIC, DIURETIC AND VASORELAXANT ACTIVITY HAS IMPLICATED THESE SUBSTANCES IN THE CONTROL OF FLUID VOLUME AND BLOOD PRESSURE. THE PROPOSED RESEARCH WILL PROVIDE RELEVANT STRUCTURE-ACTIVITY DATA FOR THESE PEPTIDES WITH THE SHORT-TERM GOAL OF PREPARING ANALOGS THAT CONTAIN THE MINIMALLY REQUIRED AMINO ACID SEQUENCE FOR SIGNIFICANT EXPRESSION OF BIOLOGICAL ACTIVITY. FROM THIS STUDY WE WILL SEE IF ANF ANALOGS FORM A BASIS FOR RATIONAL NEW THERAPEUTIC APPROACHES FOR TREATMENT OF CARDIOVASCULAR DISEASE. THE PROPOSED STUDY WILL ESTABLISH A STARTING POINT FOR FUTURE ANALOG DESIGN WITH THE ULTIMATE GOAL OF OBTAINING ORALLY ACTIVE, METABOLICALLY STABLE ANF AGONISTS.

* information listed above is at the time of submission.

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