ENDOGENOUS ANTI-INFLAMMATORY PROTEIN: BIOLOGICAL TESTING

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
2945
Agency Tracking Number:
2945
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2450 Bayshore Frontage Road, Mountain View, CA, 94043
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Lorin K. Johnson
Principal Investigator
(415) 966-1550
Business Contact:
() -
Research Institution:
n/a
Abstract
INFLAMMATORY DISORDERS ACCOUNT FOR A SIGNIFICANT PERCENTAGE OF DEBILITATING DISEASES. IT IS NOW APPARENT THAT CENTRAL TO THE THERAPEUTIC CONTROL OF THE INFLAMMATORY REACTION IS THE REGULATION OF THE PHOSPHOLIPID METABOLITES, THE EICOSANOIDS. IN MOST TISSUES THE SYNTHESIS OF THE EICOSANOIDS IS LIMITED BY THE AVAILABILITY OF ARACHIDONIC ACID (AA) WHICH IS FIRST LIBERATED FROM MEMBRANE PHOSPHOLIPIDS BY THE ACTIVITY OF PHOSPHOLIPASE A2 (PLA2). THE GOAL OF THE PROPOSED WORK IS THEREFORE TO TEST THE BIOLOGICAL EFFICACY OF AN ENDOGENOUS INHIBITOR OF PLA2 ISOLATED FROM HUMAN SOURCES. PHASE I IS DIRECTED TOWARDS: 1.DETERMINING THE HALF-LIFE OF THE INHIBITOR WHEN INJECTED I.V. INTO EXPERIMENTAL ANIMALS; 2.DETERMINING IF THE INHIBITOR MAY DISRUPT THE PROSTACYCLIN/THROMBOXANE A2 BALANCE; 3.DETERMINING IF THE INHIBITOR IS EFFECTIVE AS AN ANTI-INFLAMMATORY THERAPEUTIC IN ACUTE MODELS OF INFLAMMATION BY ASSESSING ITS EFFECT ON RAT HINDPAW EDEMA, PLEURAL CAVITY INFLAMMATION, AND ADJUVANT-INDUCED POSITIVE RESULTS OF THE PHASE I RESEARCH WILL LEAD TO THE DEVELOPMENT IN PHASE II OF AN ACTIVE, SYNTHETIC FRAGMENT OF THE PLA2 INHIBITOR AND TO ITS DELIVERY USING AN ADJUVANT-DIRECTED NASAL DELIVERY SYSTEM. THE RESULTS COULD LEAD TO THE DEVELOPMENT OF AN ANTI-INFLAMMATORY THERAPEUTIC WHICH DOES NOT CARRY THE SIDE EFFECTS AND TOXICITY OF EXISTING NONENDOGENOUS ANTI-INFLAMMATORY DRUGS AND COULD BE USED TO TREAT ARTHRITIS, SYSTEMIC LUPUS, PSORIASIS, AND POSSIBLY ATHEROSCLEROSIS.

* information listed above is at the time of submission.

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