ACCELERATED WOUND HEALING WITH FIBROBLAST GROWTH FACTOR

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4931
Amount: $500,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1988
Solitcitation Year: N/A
Solitcitation Topic Code: N/A
Solitcitation Number: N/A
Small Business Information
California Biotechnology Inc.
2450 Bayshore Frontage Rd, Mountain View, CA, 94043
Duns: N/A
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 John C Fiddes
 Principal Investigator
 (415) 966-1550
Business Contact
Phone: () -
Research Institution
N/A
Abstract
BASIC AND ACIDIC FIBROBLAST GROWTH FACTORS (FGF) ARE TWO PRIMARY MITOGENS FOR CAPILLARY ENDOTHELIAL CELLS. BOVINE BASIC FGF, ISOLATED FROM PITUITARIES, WILL BE USED IN RAT WOUND HEALING MODELS TO DETERMINE WHETHER THIS FACTOR CAN ACCELERATE THE RATE OF WOUND HEALING THROUGH PROMOTING ANGIOGENESIS. THIS IS THE FIRST STEP TOWARDS DEVELOPING A THERAPY THAT WILL BE USED IN THE TREATMENT OF BURN AND OTHERTRAUMA VICTIMS WHO HAVE POORLY HEALING WOUNDS. TO OBTAIN A SOURCE OF THE HUMAN FGFS, FOR FURTHER ANIMAL TESTS AND FOR EVENTUAL CLINICAL TRIALS, THE DNA SEQUENCES ENCODING BOTH BASIC AND ACIDIC FGF WILL BE CLONED. THIS WILL ALLOW THE FUTURE DEVELOPMENT OF RECOMBINANT DNA EXPRESSION SYSTEMS FORHUMAN PROTEINS.

* information listed above is at the time of submission.

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