ACCELERATED WOUND HEALING WITH FIBROBLAST GROWTH FACTOR

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
4931
Agency Tracking Number:
4931
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2450 Bayshore Frontage Rd, Mountain View, CA, 94043
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
John C Fiddes
Principal Investigator
(415) 966-1550
Business Contact:
() -
Research Institute:
n/a
Abstract
BASIC AND ACIDIC FIBROBLAST GROWTH FACTORS (FGF) ARE TWO PRIMARY MITOGENS FOR CAPILLARY ENDOTHELIAL CELLS. BOVINE BASIC FGF, ISOLATED FROM PITUITARIES, WILL BE USED IN RAT WOUND HEALING MODELS TO DETERMINE WHETHER THIS FACTOR CAN ACCELERATE THE RATE OF WOUND HEALING THROUGH PROMOTING ANGIOGENESIS. THIS IS THE FIRST STEP TOWARDS DEVELOPING A THERAPY THAT WILL BE USED IN THE TREATMENT OF BURN AND OTHERTRAUMA VICTIMS WHO HAVE POORLY HEALING WOUNDS. TO OBTAIN A SOURCE OF THE HUMAN FGFS, FOR FURTHER ANIMAL TESTS AND FOR EVENTUAL CLINICAL TRIALS, THE DNA SEQUENCES ENCODING BOTH BASIC AND ACIDIC FGF WILL BE CLONED. THIS WILL ALLOW THE FUTURE DEVELOPMENT OF RECOMBINANT DNA EXPRESSION SYSTEMS FORHUMAN PROTEINS.

* information listed above is at the time of submission.

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