PURIFICATION OF AN AUTOCRINE ANGIOGENESIS INHIBITOR

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
7316
Agency Tracking Number:
7316
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2450 Bayshore Frontage Road, Mountain View, CA, 94043
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
MARK A SNYDER PHD
(415) 966-1550
Business Contact:
() -
Research Institute:
n/a
Abstract
A PROTEIN HAS BEEN IDENTIFIED FROM A CULTURED CELL LINE WHICH INHIBITS THE GROWTH OF CAPILLARY ENDOTHELIAL CELLS IN VITRO. THIS PROTEIN WILL BE PURIFIED FROM CONDITIONED GROWTH MEDIUM AND USED IN IN VITRO AND IN VIVO MODEL SYSTEMSTO TEST ITS ABILITY TO INHIBIT THE FORMATION OF NEW CAPILLARIES. THIS IS THE FIRST STEP TOWARD DEVELOPING A THERAPY THAT WILL BE USED IN THE TREATMENT OF SOLID TUMORS, VARIOUS RETINOPATHIES, PSORIASIS, ARTERIAL OCCLUSIVE DISEASE, AND IN BIRTH CONTROL, ALL OF WHICH INVOLVE EITHER NEOVASCULARIZATION OR GROWTH OF ENDOTHELIAL CELLS THEMSELVES.

* information listed above is at the time of submission.

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