ANTIBODIES TO ATRIAL PEPTIDE RECEPTOR

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$490,968.00
Award Year:
1990
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
11457
Agency Tracking Number:
11457
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2450 Bayshore Frontage Rd, Mountain View, CA, 94043
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
ATRIAL NATRIURETIC PEPTIDE (ANP) BINDS TO MULTIPLE CELL SURFACE RECEPTORS IN A NUMBER OF DIFFERENT TISSUES, RESULTING IN EFFECTS RELATED TO CARDIOVASCULAR HOMEOSTASIS. THIS RESEARCH INVOLVES THE GENERATION OF SPECIFIC ANTIBODIESTO A CLONED ANP RECEPTOR THAT APPEARS TO FUNCTION IN THE METABOLIC CLEARANCE OF ANP. SPECIFICALLY, IT IS PLANNED TO USE A RECOMBINANT VACCINIA VIRUS EXPRESSING CLONED RECEPTOR SEQUENCES TO GENERATE ANP-RECEPTOR-SPECIFIC ANTISERA. THE RECEPTOR, TERMED THE C-ANP RECEPTOR, IS A THERAPEUTICALLY IMPORTANT TARGET BECAUSE ANP ANALOGS THAT BIND TO THIS RECEPTOR LEAD TO AN INCREASE IN ENDOGENOUS ANP LEVELS. POLYCLONAL AND MONOCLONAL ANTIBODIES THAT CAN BIND TO THIS SPECIFIC CLASS OF RECEPTORS AND/OR INHIBIT THE LIGAND-RECEPTOR INTERACTION WILL BE VALUABLE IN DISCERNING THE PHYSIOLOGICAL ROLE, TISSUE DISTRIBUTION, AND MOLECULAR ARCHITECTURE OF THE ANP RECEPTOR UNDER VARIOUS NORMAL AND PATHOLOGIC CONDITIONS. IN ADDITION, THE ANTIBODIES WILL BE IMPORTANT TOOLS TO AID IN THE DESIGN OF THERAPEUTIC AGENTS THAT INTERACT WITH THIS RECEPTOR.

* information listed above is at the time of submission.

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