INHIBITORS OF ATRIAL NATRIURETIC PEPTIDE CLEARANCE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$467,104.00
Award Year:
1991
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
11458
Agency Tracking Number:
11458
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2450 Bayshore Frontage Rd, Mountain View, CA, 94043
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institute:
n/a
Abstract
THE ATRIAL NATRIURETIC PEPTIDE (ANP) HORMONAL SYSTEM, WHICH HAS AN IMPORTANT BIOLOGICAL ROLE IN FLUID AND ELECTROLYTE HOMEOSTASIS, REPRESENTS AN IMPORTANT NEW THERAPEUTIC TARGET FOR CARDIOVASCULAR DISEASE STATES. THIS RESEARCH IS BASED ON THE RECENT IDENTIFICATION OF A NOVEL MECHANISM FOR CLEARANCE OF ENDOGENOUS ATRIAL PEPTIDES THROUGH INTERACTION WITH SPECIFIC ANP BINDING SITES (C-ANP RECEPTORS) THAT DO NOT APPEAR TO MEDIATE ANY OF THE KNOWN BIOLOGICAL ACTIONS OFANP'S. ANP ANALOGS THAT BIND TO AND SATURATE C-ANP RECEPTORS CAUSE ENDOGENOUS ANP LEVELS TO INCREASE, ALLOWING THERAPEUTICALLY DESIRABLE RENAL AND BLOOD-PRESSURE-LOWERING EFFECTS TO BE OBSERVED. THIS STUDY WILL EXAMINE THE STRUCTURE-ACTIVITY RELATIONSHIPS OF C-ANP RECEPTOR-SPECIFIC LIGANDS FOR THE PURPOSE OF DEVELOPING INHIBITORS OF ANP CLEARANCE. THIS RESEARCH IS AIMED AT THE GENERATION OF A NEW CLASS OF ORALLYACTIVE, STABLE COMPOUNDS THAT HAVE THERAPEUTIC UTILITY IN TREATING HYPERTENSION, HEART FAILURE, AND RELATED EDEMATOUS STATES.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government