AN IN VITRO SCREEN FOR ATYPICAL BETA-ADRENERGIC AGONISTS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1990
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
13801
Agency Tracking Number:
13801
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2450 Bayshore Pkwy, Mountain View, CA, 94043
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
R Tyler White
(415) 966-1550
Business Contact:
() -
Research Institute:
n/a
Abstract
THE ULTIMATE GOAL OF THIS RESEARCH IS TO DEVELOP A THERAPY FOR OBESITY BASED UPON THE IDENTIFICATION OF NOVEL BETA-ADRENERGIC AGONISTS THAT ARE SELECTIVE STIMULATORS OF THERMOGENESIS IN HUMANS. ATYPICAL (NON-BETA1, BETA2) BETA-ADRENERGIC RECEPTORS (BETA-ARS) ARE THOUGHT TO MEDIATE SYMPATHETIC NERVOUS SYSTEM STIMULATION OF THERMOGENESIS. ATYPICAL BETA- AGONISTS HAVE BEEN SHOWN TO STIMULATE THERMOGENESIS AND PROMOTE WEIGHT LOSS IN ANIMAL MODELS AND IN HUMAN CLINICAL TRIALS, BUT DESPITE THEIR RELATIVE SELECTIVITY, INTERACTIONS WITH BETA1-AR AND BETA2-AR PRODUCE SIDE EFFECTS. IMPROVEMENTS IN AGONIST SELECTIVITY FOR STIMULATION OF THERMOGENESIS WOULD LEAD TO USEFUL THERAPEUTICS. THE SPECIFIC AIM OF THE PROPOSED RESEARCH IS TO ESTABLISH A SCREENING SYSTEM FOR SELECTIVE THERMOGENIC BETA-AGONISTS. DURING PHASE I, THE POLYMERASE CHAIN REACTION (PCR) AND MOLECULAR CLONING TECHNIQUES WILL BE EMPLOYED TO IDENTIFY AND ISOLATE GENES FOR ATYPICAL BETA-ARS EXPRESSED IN TISSUESTHAT ARE SITES FOR THERMOGENESIS IN HUMANS. DURING PHASE II, THE GENES FOR ATYPICAL BETA-ARS WILL BE INTRODUCED INTO CHINESE HAMSTER OVARY CELLS TO ESTABLISH A MATRIX OF CELL LINES EXPRESSING FUNCTIONAL ATYPICAL RECEPTORS, WHICH WILL THEN BE USED TO SCREEN POTENTIAL THERMOGENIC AGONISTS.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government