WOUND REPAIR WITH HEPARIN-BINDING EGF-LIKE GROWTH FACTOR

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 16641
Amount: $414,744.00
Phase: Phase II
Program: SBIR
Awards Year: 1993
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
2450 Bayshore Parkway, Mountain View, CA, 94043
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Abraham, Judith A
 Principal Investigator
 (415) 966-1550
Business Contact
 1 R43 GM46166-01
Phone: () -
Research Institution
N/A
Abstract
USING HEPARIN AFFINITY CHROMATOGRAPHY, A NOVEL FIBROBLAST AND VASCULAR SMOOTH MUSCLE CELL MITOGEN HAS BEEN ISOLATED FROM THE CONDITIONED MEDIUM OF THE HUMAN HISTIOCYTIC LYMPHOMA CELL LINE U-937. ANALYSIS OF CDNA CLONES HAS SHOWN THAT THIS FACTOR IS A NEW MEMBER OF THE EGF/TGFALPHA FAMILY OF PROTEINS, AND IT HAS THEREFORE PROVISIONALLY BEEN NAMED HEPARIN-BINDING EGF-LIKE GROWTH FACTOR (HBEGF). AMPLE EVIDENCE HAS NOW ACCUMULATED INDICATING THAT VARIOUS ASPECTS OF THE PROCESS OF WOUND REPAIR CAN BE ACCELERATED BY THE APPLICATION OF PARTICULAR GROWTH FACTORS. THE LONG-TERM OBJECTIVES OF THIS PROJECT ARE THEREFORE (I) TO DETERMINE WHETHER HBEGF IS EFFICACIOUS IN ACCELERATING NORMAL AND/OR VARIOUS TYPES OF IMPAIRED WOUND HEALING; AND (II) TO DETERMINE WHETHER HBEGF HAS IN VIVO ACTIVITIES THAT DISTINGUISH IT THERAPEUTICALLY FROM OTHER KNOWN GROWTH FACTORS. THE PRINCIPAL GOAL OF PHASE I OF THE PROJECT IS TO GENERATE REAGENTS (HBEGF RECOMBINANTLY PRODUCED IN BACTERIA OR MAMMALIAN CELLS; ANTIBODIES AGAINST HBEGF) TO ALLOW A MORE DETAILED STUDY OF THE BIOLOGY OF THIS FACTOR. IN ADDITION, AN INITIAL TEST OF THE WOUND HEALING ACTIVITY OF HBEGF WILL BE CONDUCTED IN A FULL-THICKNESS WOUND MODEL IN IMPAIRED (DIABETIC, DB/DB) MICE.

* Information listed above is at the time of submission. *

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