ISOLATION OF INSULIN RECEPTOR PHOSPHATASES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1991
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
16535
Agency Tracking Number:
16535
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
California Biotechnology, Inc (Currently California Biotechnology, Inc.)
2450 Bayshore Parkway, Mountain View, CA, 94043
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Sweet, Laurel J
Principal Investigator
(415) 966-1550
Business Contact:
1 R43 DK44046-01
() -
Research Institution:
n/a
Abstract
THE ULTIMATE OBJECTIVE OF THIS RESEARCH IS TO DEVELOP A NOVEL TREATMENT FOR DIABETES BASED ON THE ENHANCEMENT OF INSULIN ACTION THROUGH THE INHIBITION OF AN INSULIN RECEPTOR-SPECIFIC PHOSPHOTYROSINE PHOSPHATASE (PTPASE). PHOSPHORYLATION OF THE INSULIN RECEPTOR BETA-SUBUNIT, IN RESPONSE TO INSULI BINDING, HAS BEEN CORRELATED WITH ACTIVATION OF THE PLEIOTROPHIC INTRA- CELLULAR INSULIN SIGNAL. MODULATION OF THE PHOSPHORYLATION STATE OF THE INSULIN RECEPTOR COULD AFFECT POST-RECEPTOR SIGNALLING EVENTS. THE SPECIFIC AIMS OF THIS PROJECT ARE TO IDENTIFY AND PURIFY AS INSULIN RECEPTOR PTPASE(S). DURING PHASE I, WE WILL IDENTIFY AND PARTIALLY PURIFY AN INSULIN RECEPTOR-SPECIFIC PTPASE. THE SPECIFICITY OF THE PHOSPHATASE WILL BE EXAMINED COMPARING DEPHOSPHORYLATION OF THE INSULIN RECEPTOR TO OTHER PHOSPHOTYROSINE, PHOSPHOSERINE, AND PHOSPHOTHREONINE-CONTAINING SUBSTRATES. DURING PHASE II, WE WILL CONTINUE PURIFICATION, GENERATE MONOCLONAL ANTIBODIES, AND IDENTIFY THE CDNA ENCODING THE INSULIN RECEPTOR PTPASE ACTIVITY.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government