Nanotechnology-Based Environmental Smart Sensors for Personal Health Exposure Monitoring

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43ES026500-01
Agency Tracking Number: R43ES026500
Amount: $150,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIEHS
Solicitation Number: PA14-071
Timeline
Solicitation Year: 2015
Award Year: 2016
Award Start Date (Proposal Award Date): 2016-02-01
Award End Date (Contract End Date): 2017-07-31
Small Business Information
405 OAK BROOK CT SE, Smyrna, GA, 30082-4611
DUNS: 079182562
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 KRISHNA NAISHADHAM
 (770) 573-0584
 knaisha1@gmail.com
Business Contact
 KRISHNA NAISHADHAM
Phone: (770) 573-0584
Email: knaisha1@gmail.com
Research Institution
N/A
Abstract
DESCRIPTION provided by applicant A broad goal of the proposed research is to develop personal exposure monitors comprising wearable wireless sensor arrays to detect harmful air pollutants within the breathing zone and improve the assessment of causative exposure dose response relationships in epidemiological studies Heterogeneous orthogonal detectors comprising functionalized carbon nanotube CNT based resonators will be designed and integrated with a smart phone platform targeting the detection of ambient ozone O in Phase particulate matter NOx and VOCs in Phase Ozone not only influences climatic changes globally through greenhouse gas emissions but also produces adverse health effects in humans as a secondary pollutant in urban smog through precursors generated in traffic and industrial pollution As a powerful oxidant gas O can elicit a range of physiological responses once inhaled including reduced lung function and inflamed airways exacerbating respiratory diseases such as asthma Numerous research efforts address the relationship between ozone exposure and health outcomes including mortality and morbidity hospitalizations decrements in lung function and asthma status but due to lack of personal exposure data considerable error may be introduced in assessing dose response relationships Currently there are no existing sensors in the market suitable for real time O exposure measurement within the breathing zone Phase research develops an ozone exposure detector array fabricated using two classes of nanosensors a polybutadiene polymer functionalized CNT thin films b CNT thin films decorated with Pt or Pd metallic nanoparticles Both offer maximum sensitivity to ozone while reducing cross sensitivity to interferents such as NOx These detector films are integrated with compact radio frequency RF resonators which respond with unique resonance shift caused by molecular level gas adsorption on the film interface In contrast to a chemiresistor both amplitude and frequency shifts in this RF nanosensor may be used to minimize false positives for robust discrimination Differential signaling between the primary sensor and a reference sensor pure CNTs compensates for environmental factors such as humidity further improving selectivity The differential signal is wirelessly interfaced through a microcontroller t a smart phone for data display of concentration levels and data communication to public health professionals or regulatory bodies via participatory and ubiquitous sensing Additionally sensors embedded in the mobile phone yield information on motion physical activity time stamp and GPS location of the subject that can be correlated to the exposure A prototype O sensor will be developed and its performance characterized under controlled laboratory and ambient conditions Field tests will be conducted on human volunteers to detect ambient ozone as a function of time over several days and results compared directly with measurements made by standard badge samplers Causative relationships will be explored by measuring eNO concentrations following the exposure in collaboration with an environmental epidemiologist PUBLIC HEALTH RELEVANCE The importance of the proposed ozone sensors with regard to public health is highlighted by the fact that EPAandapos s stringent National Ambient Air Quality Standard NAAQS for ozone emission levels are exceeded in many parts of the US and there is a tremendous need to better characterize the spatial and temporal distributions of ozone The proposed research has significant potential to reduce health care costs by enhancing the understanding of causative exposure dose respiratory health effects through improved accuracy and enhanced population size in public health studies In conjunction with embedded sensors such as D accelerometers heart rate respiration rate fitness tracking and many more existing or proposed smart phone utilities the proposed mobile personal exposure monitors can potentially enhance epidemiological population studies and gather rich metadata on environmental pollutants and their exposure effects on humans as a function of location season and physical activity The long term vision of the proposed work Phase and beyond is to develop reliable low cost sensors to simultaneously measure the external exposure to multiple environmental pollutants and integrate these chemical sensors with biosensors for measuring the levels of toxicants in biological specimens obtained from an individual such as blood saliva exhaled breath sweat or urine Thus the exposure measurements of the proposed sensor can be combined with diagnostic tools to assess an individualandapos s internal dosage and physiological effects thereby providing comprehensive exposure assessment from source to dose

* Information listed above is at the time of submission. *

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