High-Efficiency Tunable Fluorescence Emission Filter

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 MH53690-1,
Agency Tracking Number: 25209
Amount: $686,507.00
Phase: Phase II
Program: SBIR
Awards Year: 1996
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
21 Erie Street, Cambridge, MA, 02139
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Clifford Hoyt
 (617) 491-2627
Business Contact
Phone: () -
Research Institution
N/A
Abstract
Tunable filters developed by us, based on electrically-tuned liquid crystal waveplates, providefluorescence microscopists with fast, continuous and automated selection of emission wavelengthwithout vibration, image shift, or detectable degradation of image quality. They can be used to convertany high-resolution monochromatic camera into a multispectral camera. On the other hand, these liquidcrystal tunable filters (LCTF's) presently offer rather low throughput (10 to 25%) which limits theirusefulness in photon-limited fluorescence applications. Our aim is to determine the feasibility ofdeveloping a new type of liquid crystal tunable filter with efficiency of 70% or more. Improvements inefficiency will accrue mainly from: 1) use of a novel optical configuration that filters all input polarizationstates instead of just one linear polarization state; and 2) improving the efficiency of our liquid crystaltunable waveplates.

* Information listed above is at the time of submission. *

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