Service and Software Solution for the Rigorous Design of Animal Studies

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 4R44DA041757-02
Agency Tracking Number: R44DA041757
Amount: $997,711.00
Phase: Phase II
Program: SBIR
Awards Year: 2017
Solicitation Year: 2015
Solicitation Topic Code: NIDA
Solicitation Number: DA16-003
Small Business Information
SERALOGIX
2505 ALLSTON LN., Austin, TX, 78746-1918
DUNS: 119169386
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 KENNETH DRAKE
 (512) 327-2617
 drake@seralogix.com
Business Contact
 KENNETH DRAKE
Phone: (512) 828-7955
Email: drake@seralogix.com
Research Institution
N/A
Abstract
The primary goal of this fast track project is to commercialize a cloud based software suite complemented with on call expert services to guide life science researchers that may have minimal statistical and experimental design ED knowledge to rigorously plan optimize justify manage and report results for complex animal studies Inadequately planned experiments e g lack of randomization blinding and diversity low sample size high test variabilities etc can introduce bias and limit statistical power both of which may lead to possible misinterpretations of results and ineffective use of resources Such deficiencies and poor quality reporting can lead to irreproducible results and may mislead the scientific community Compounding the problem is the complex nature of the studies themselves such as species diversity strain sex groupings litters randomization sample size power sampling times analysis and treatment plans outcome variability and cost tradeoffs that all must be considered when optimizing EDs Some of these issues may be caused by a lack of access to statisticians test method knowledge i e variabilities and planning tools or a lack of rigorous training in ED methods A collaborative initiative was created by Seralogix to include experts from the University of Texas FDA University of Utah University of Edinburgh and the Broad Insitute Addressing these issues Seralogix and our collaborators will implement an intelligent knowledge driven cloud application and service portal for ED planning and optimization called the Statistically Rigorous Experimental Animal Study Designer i e SHREWD We believe that SHREWD will lead to a reduction in animal use savings in financial and scientific resources and will improve the scientific validity of the study results through the rigorous collection of data following well planned and executed experimental designs This project will commercialize a cloud based software suite complemented with on call expert services to guide life science researchers that may have minimal statistical and experimental design ED knowledge to rigorously plan optimize justify manage and report results for complex animal studies The software may lead to a reduction in animal use savings in financial and scientific resources and will improve the scientific validity of the study results through the rigorous collection of data following well planned and executed experimental designs

* information listed above is at the time of submission.

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