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BIOPOLYMER FOR MAXILLOFACIAL REPAIR

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 13785
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1990
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
195 Common St
Belmont, MA 02178
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Joseph D Gresser
 (617) 484-3184
Business Contact
Phone: () -
Research Institution
N/A
Abstract

IT IS PLANNED TO INVESTIGATE A BIOPOLYMERIC REPAIR MATERIAL FOR MAXILLOFACIAL REPAIR. BASED ON AN INDEPENDENT, INITIAL FEASIBILITY PROJECT, PHASE I EFFORTS WILL FORMULATE AND CHARACTERIZE THE COMPONENTS OF THIS NOVEL BIOPOLYMERIC MATERIAL. MECHANICAL TESTING AND IN VIVO EVALUATIONS WILL ALSO BE CONDUCTED. BASIC TO THIS BONE REPAIR MATERIAL IS A COMPOSITION CONTAINING THE BIOPOLYMER POLY(PROPYLENE FUMARATE), WHICH ISAN UNSATURATED CROSS-LINKABLE POLYMER MADE FROM FUMARIC ACID, ONE OF THE KREBS CYCLE ACIDS, AND POLYLENE GLYCOL, A COMMONLY USED DILUENT IN PARENTERAL DRUG FORMULATIONS. THISBIOPOLYMER, IN POWDERED FORM, IS USED TO INCORPORATE AN ADSORBABLE FILLER, SUCH AS A POWDERED CALCIUM PHOSPHATE OR PARTICULATE BONE. WHEN THE POWDERED BIOPOLYMER AND ADSORBABLE FILLER ARE HAND-BLENDED TOGETHER, ALONG WITH A SUITABLE CROSS-LINKING AGENT, A USEFUL BONE REPAIR "PUTTY," OR GROUT, RESULTS. THIS HAND-WORKABLE BONE GROUT SOLIDIFIES IN 15 MINUTES AT PHYSIOLOGICAL TEMPERATURES WITH VIRTUALLY NO OBSERVABLE HEAT OF REACTION AND HAS PHYSICAL PROPERTIES SUITABLE FOR THE INTENDED APPLICATION. FUTHER, CONTROLLED-RELEASE ANTIBIOTICS AND GROWTH FACTORS MAY BE INCORPORATED INTO THIS FORMULATION WITH THE OBJECTIVE OF BEING RELEASED IN A PREDESIGNED MANNER.

* Information listed above is at the time of submission. *

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