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Stable Biodegradable Polymers for Delivery of Both Polar and Non-Polar Drugs

Award Information
Agency: Department of Defense
Branch: Army
Contract: N/A
Agency Tracking Number: 32798
Amount: $598,742.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 1997
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
195 Common St.
Belmont, MA 02178
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Joseph D. Gresser, Ph.d.
 (617) 373-2994
Business Contact
Phone: () -
Research Institution

The development of a controlled release implant for pain relief of pain is described. The analgesic hydromorphone is proposed for incorporation into a biodegradable excipient designed for continuous release for one week to several weeks. The proposed relatively short duration minimizes the possibility of dependence and permits flexibility in dosing by recognizing that delivery for longer periods may not be necessary. The excipient uses a modified poly(lactide-co-flycolide), PLGA, prepared as a porous, open celled foam into which the drug is incorporated as microcrystals trapped within the cells. The foam/drug matrix is extruded under high pressure to produce a high density nonporous dose form which is then cryogenically ground and sieved to small particles suitable for injection by a conventional hypodermic needle. This method of matrix fabrication may be applied to both polar and nonpolar agents. Generally polar agents will be more soluble than nonpolar, and will release faster. Release rates may be controlled by choice of lactide:glycolide copolymer rations, polymer molecular weight, loading, and extrusion pressure.

* Information listed above is at the time of submission. *

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