Quantitative I-123 Cardiac SPECT using a Novel Spectral Fitting Method for High E

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43HL090118-01A1
Agency Tracking Number: HL090118
Amount: $117,839.00
Phase: Phase I
Program: SBIR
Awards Year: 2008
Solicitation Year: 2008
Solicitation Topic Code: N/A
Solicitation Number: PHS2007-2
Small Business Information
DUNS: 626962596
HUBZone Owned: Y
Woman Owned: Y
Socially and Economically Disadvantaged: Y
Principal Investigator
 () -
Business Contact
Phone: (816) 531-2842
Research Institution
DESCRIPTION (provided by applicant): Current emphasis on metabolic approaches and models for diagnosing heart disease have renewed development of 123I SPECT imaging agents applied in stand-alone protocols and as a complimentary role to existing stress/rest perfusion protocols. However, a majority of the current nuclear cardiology SPECT equipment base and associated infrastructure utilize low energy (LE) collimation which is a significant technical obstacle to adapting 123I imaging due to spectrum contaminan ts from high energy (gt 500 keV) 123I emissions. Medium energy (ME) collimation for SPECT imaging is typically applied in general nuclear environments for 123I imaging, but is not readily available or nonexistent for nuclear cardiology large field of view systems and not at all available for small field of view dedicated cardiac SPECT systems. The primary objective of this work is to develop an energy-based algorithmic method allowing efficient and accurate imaging of 123I agents on existing nuclear cardiol ogy equipment employing low energy collimation while improving image accuracy in comparison with ME collimation thereby facilitating adaptation of cardiac 123I SPECT. The technique employs a list mode acquisition that improves the effective energy resoluti on of the gamma camera by iteratively estimating a spectrum free' of the spectral contaminants. The technique does not rely on assumptions about the patient habits or require the acquisition of additional data for modeling the scatter component.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government