Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: PHS2001-2
Agency Tracking Number: 1R41NS041124-01
Amount: $104,523.00
Phase: Phase I
Program: STTR
Awards Year: 2001
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
BOX 3136, LARAMIE, WY 82071-3136, LARAMIE, WY, 82071
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (307) 742-6638
Business Contact
 Robert C. Corcoran
Phone: (307) 766-4315
Research Institution
LARAMI, WY, 82071
 Nonprofit college or university
DESCRIPTION (adapted from applicant's abstract): The long-term goal of this project is to develop a rapid, safe, and sensitive test for the abnormal isofomms of prion (PrP/res) proteins associated with the transmissible spongifomm encephalopathies (TSE). The Surface Enhanced Raman Immunoassay (SERIA) assay to be evaluated will facilitate testing of samples with a minimum of handling (for safety and speed) at a high level of sensitivity and specificity. This will allow development of ante mortem tests in addition to application of the assay to postmortem diagnosis of TSEs. Availably of such tests will support (a) diagnostic testing of patients potentially affected by TSEs, (b) rapid screening of animal and possibly human populations for TSEs by ante mortem (blood, Lymphoid tissues, etc.) or postmortem (Lymphoid tissues, brain) testing and, (c) studies that seek to better understand the pathogenesis of TSEs. Chronic Wasting Disease (CWD) of deer and elk will be used as a model for other TSEs. Specific goals are to evaluate sensitivity of the SERIA for CWD PrP/res in brain and blood samples and to determine specificity of the SERIA for CWD PrP/res in brain and blood samples. PROPOSED COMMERCIAL APPLICATION: Currently there are no antemortem test for TSE. This will represent the first such test and will have commercial application for testing patients suspected to have TSE. A much larger commercial application will be the screening of domestic animals to eliminate TSE.

* Information listed above is at the time of submission. *

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