Neural Stem Cells From Umbilical Cord Blood

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: PHS2001-2
Agency Tracking Number: 1R41NS042431-01
Amount: $107,000.00
Phase: Phase I
Program: STTR
Awards Year: 2001
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
CCEL BIO-THERAPIES, INC.
3165 MC MULLEN BOOTH RD, BLDG 5, CLEARWATER, FL 33761, CLEARWATER, FL, 33761
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 JUAN SANCHEZRAMOS
 (813) 974-5841
 JSRAMOS@HSC.USF.EDU
Business Contact
 RICHARD, DAN
Phone: (727) 723-0333
Research Institution
 UNIVERSITY OF SOUTH FLORIDA
 UNIVERSITY OF SOUTH FLORIDA
TAMPA, FL, 33620
 Nonprofit college or university
Abstract
DESCRIPTION (provided by applicant): A neural stem cell is a single cell with the ability to proliferate, to self-renew over the lifetime of the organism, to generate a large number of clonally-related progeny and to replace limited numbers of neural cells in the adult brain. Recently, several research teams have reported that stem cells obtained from human bone marrow can be induced to differentiate into cells of neuronal and glial phenotype, both in vitro and in vivo. Preliminary results show that umbilical cord blood is a more abundant, readily accessible source of neural precursors than bone marrow. Through isolation, expansion and differentiation of neural stem cells from cord blood, it may be possible to provide enough neural precursors to treat, through transplantation, a variety of neurological deficits induced by neurodegenerative disease, genetic deficit, or injury. This Phase I research program proposes to isolate and characterize neural precursors from the heterogeneous population of mononuclear cells, which comprise umbilical cord blood. The optimal conditions for isolating and differentiating these cells into mature neural cells will be determined. Finally, it will be shown that the neural precursor cells can produce recovery on tests of motor and cognitive function in an animal model of brain injury. The success of directing stem cells obtained from umbilical cord blood into a neural phenotype has important implications for the therapeutic potential of stem cells in neural transplantation in humans. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

* information listed above is at the time of submission.

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