INFORMATION RESOURCE ACTIVITIES IN CHEMOPREVENTION LITERA- TURE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$250,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
7625
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Ccs Associates
1285 Hamilton Avenue, Palo Alto, CA, 94301
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Caroline C. Sigma, Ph.d.
(415) 328-7876
Business Contact:
() -
Research Institution:
n/a
Abstract
THE OBJECTIVE OF THIS PROJECT IS THE DEVELOPMENT OF A COMPREHENSIVE INFORMATION RESOURCE ON CHEMOPREVENTION THAT MAY BE APPLIED TO THE IDENTIFICATION OF CHEMOPREVENTIVE AGENTS AND TO OTHER RESEARCH AND DEVELOPMENT PROBLEMS IN CHEMOPREVENTIOTHE DEVELOPMENT OF CHEMOPREVENTIVE AGENTS IS A HIGH-PRIORITYRESEARCH EFFORT AT NCI, PARTICULARLY FOR AGENTS THAT ARE EF-FICACIOUS AND SAFE FOR USE IN PATIENTS AT HIGH RISK FOR DEVELOPING CERTAIN TYPES OF CANCERS. A PRIMARY RESULT OF PHASE I OF THIS PROJECT WAS THE DEVELOP-MENT OF A MASTER LIST DATABASE OF 543 POTENTIAL CHEMOPREVEN-TIVE AGENTS, WITH INDICATORS OF EFFICACY AND LITERATURE REF-ERENCES. THE INFORMATION ON EFFICACY INCORPORATED INTO THIS DATABASE WAS THAT INFORMATION JUDGED TO BE MOST USEFUL TO NCI IN PRIORITIZING AGENTS FOR FURTHER STUDY. IN PHASE II, THE MASTER LIST DATABASE WILL BE UPDATED, AND DATABASES OF EFFICACY TEST RESULTS (ANIMAL BIOASSAYS, SHORT-TERM TESTS, EPIDEMIOLOGY, INTERMIDIATE MARKERS) AND TOXICITY WILL BE DEVELOPED FOR THE AGENTS INCLUDED IN THE MASTER LIST. THESE DATABASES ARE EXPECTED TO BE APPLIED TO VARIOUS ASPECTS OF RESEARCH AND DEVELOPMENT PLANNING FOR BOTH NCI AND COMMER- CIAL CLIENTS. POTENTIAL APPLICATIONS INCLUDE STRUCTURE-AC- TIVITY STUDIES, ESTABLISHING TESTING PRIORITIES, AND EVAL- UATING THE RELIABILITY OF VARIOUS TESTING PROTOCOLS.

* information listed above is at the time of submission.

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