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Screening the Ribosome for New Target Sites

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41AI120303-01A1
Agency Tracking Number: R41AI120303
Amount: $650,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIAID
Solicitation Number: PA14-308
Timeline
Solicitation Year: 2014
Award Year: 2016
Award Start Date (Proposal Award Date): 2016-07-13
Award End Date (Contract End Date): 2019-06-30
Small Business Information
900 B W FARIS RD
Greenville, SC 29605-4255
United States
DUNS: 831389122
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 DEV ARYA
 (864) 656-1106
 dparya@clemson.edu
Business Contact
 DEV ARYA
Phone: (864) 207-0002
Email: 101arya@gmail.com
Research Institution
 CLEMSON UNIVERSITY
 
230 KAPPA STREET, SUITE 200
CLEMSON, SC 29634-0001
United States

 Nonprofit college or university
Abstract

DESCRIPTION provided by applicant Nucleic acids are avenues for drug design both as therapeutics and as targets Here we propose to establish new methods for identifying antibiotic ribosome targets and lead compounds Targeting specific RNA such as rRNA which are involved in proliferation and survival of bacteria is a promising approach We are developing fast and low cost methods to screen sequence specific small molecules for novel anti ribosomal activities We will construct sequence specific ribosomal targeting oligomers as antibacterials that can be effectively delivered inside the cell Complexes between ribosomal components will be exploited as targets for small molecule drug libraries that inactivate the ribosome stopping bacterial protein synthesis and causing bacterial death NUBADs unique experimental approaches and technologies will allow us to target ribosomal regions not previously explored for susceptibility against anti bacterial agents This work addresses an important world health issue antimicrobial resistance and presents creative steps towards a novel solution to this problem The work proposed here a multidisciplinary effort encompassing solid phase organic synthesis oligonucleotide delivery RNA targeted screening and antibacterial studies describes the development of sequence specific cell permeable binders of rRNA as antibacterial therapeutics The success of the proposed work would be a significant addition to currently available ribosome specific approaches in antibacterial therapy We propose using a small rRNA target sequences to design conjugates that can be employed to inhibit bacterial growth opening possibilities for developing sequence specific RNA targeted therapeutics PUBLIC HEALTH RELEVANCE The work proposed here a multidisciplinary effort encompassing organic synthesis oligonucleotide delivery RNA targeted screening and antibacterial studies describes the development of sequence specific cell permeable binders of rRNA as antibacterial therapeutics The success of the proposed work would be a significant addition to currently available ribosome specific approaches in broad spectrum antibacterial antibiotic development in particular for targeting gram negative pathogens We propose using a small rRNA target sequences to design conjugates that can be employed to inhibit bacterial growth opening possibilities for developing sequence specific RNA targeted therapeutics

* Information listed above is at the time of submission. *

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