NEUTRALIZATION OF HIV

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$500,000.00
Award Year:
1990
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
7852
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Cellular Products Inc.
688 Main St, Buffalo, NY, 14202
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
MONOCLONAL ANTIBODIES HAVE BEEN GENERATED WHICH REACT WITH CONSERVED SITES OF THE P17 CORE PROTEIN OF THE HUMAN IMMUNODEFICIENCY VIRUS (HIV). TWO OF THESE ANTIBODIES EXERTA POTENT NEUTRALIZING EFFECT ON THE REPLICATION OF HIV IN PERMISSIVE CELLS. THE GOALS OF THIS PROPOSAL ARE TO (1) PRECISELY IDENTIFY THE P17 EPITOPES RECOGNIZED, (2) SYNTHESIZE PEPTIDES WHICH SPAN THE EPITOPES OF INTEREST, (3) GENERATE IDIOTYPIC REAGENTS CORRESPONDING TO THE BIOLOGICALLY ACTIVE ANTIBODIES AND TO (4) CHARACTERIZE THE ANTIPEPTIDE ANTISERA AND IDIOTYPIC ANTIBODIES FOR HIV NEUTRALIZATION AND INHIBITION OF VIRAL ADSORPTION TO TARGET RECEPTORS. METHODOLOGIES FOR ACHIEVING THESE GOALS INCLUDE EPITOPE MAPPING, PEPTIDE SYNTHESIS, MONOCLONAL AND POLYCLONAL ANTIBODY DEVELOPMENT AND THE USE OF HIV TRANSMISSION ASSAYS AND VIRAL ADSORPTION PROCEDURES. A COMPARATIVE EVALUATION OF THE BIOLOGICAL EFFICACY OF ANTIPEPTIDE VERSUS IDIOTYPIC ANTIBODIES WILL RESULT, ALONG WITH INFORMATION RELATING TO NOVEL SITES ON HIV STRUCTURES WHICH ARE AMENABLE TO NEUTRALIZATION.

* information listed above is at the time of submission.

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