AN IMPROVED BIOARTIFICIAL ENDOCRINE PANCREAS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,938.00
Award Year:
1990
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
13803
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Cellular Transplants Inc
4 Richmond Sq, Providence, RI, 02906
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Orion D Hegre
(401) 272-3310
Business Contact:
() -
Research Institution:
n/a
Abstract
THE LONG-TERM OBJECTIVE OF THIS RESEARCH IS THE DEVELOPMENT AND INTRODUCTION TO MEDICAL PRACTICE OF AN EFFECTIVE BIOCOMPATIBLE IMPLANTABLE HYBRID ARTIFICIAL ENDOCRINE PANCREAS THAT IS CAPABLE OF SIGNIFICANT IMPROVEMENT IN THE THERAPY OF INSULIN-DEPENDENT DIABETES. THE SPECIFIC AIM OF THIS PROJECT IS TO EXTEND AND MODIFY A PROCESS FOR CELLULAR ENCAPSULATION TO THE ISLETS OF LANGERHANS, USING A CO-EXTRUSION METHOD IN WHICH THE ISLET TISSUE IS ENCLOSED WITHIN THE POLYMERIC MEMBRANE CAPSULE AT THE TIME OF ITS FORMATION. THE RESEARCH PROGRAM WILL DEFINE CONDITIONS OF A MACROCAPSULE CONTAINING PHYSIOLOGICALLY RESPONSIVE INSULIN-SECRETING ENDOCRINE TISSUE. DEVELOPMENT OF THIS TECHNOLOGY MAY PERMIT THE EFFICACIOUS USE OF ANIMAL CELLS INAN IMMUNOISOLATED ENVIRONMENT FOR THE EARLY TREATMENT OF INSULIN-DEPENDENT DIABETES AND THUS IMPACT POSITIVELY ON THEPREVENTION OF THE DEBILITATING SECONDARY COMPLICATIONS ASSOCIATED WITH THE DISEASE.

* information listed above is at the time of submission.

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