STTR Phase I: Development of Bacterial Glycorandomization Hosts

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 0740027
Agency Tracking Number: 0740027
Amount: $75,000.00
Phase: Phase I
Program: STTR
Awards Year: 2008
Solicitation Year: N/A
Solicitation Topic Code: BT
Solicitation Number: NSF 07-551
Small Business Information
3750 Country Grove Drive, Madison, WI, 53719
DUNS: 787342471
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 charles hutchinson
 (510) 701-5200
Business Contact
 charles hutchinson
Title: PhD
Phone: (510) 701-5200
Research Institution
 University of Wisconsin- Madison
 Jon S. Thorson
 21 North Park Street
Suite 6401
Madison,, WI, 53715 1218
 (608) 836-0207
 Nonprofit college or university
This Small Business Technology Transfer Research Phase I project develops methodology needed for the production of sugar enhanced (glycosidic) compound libraries and final therapeutic leads. Sugar attachments have been identified as a powerful way to make therapeutically relevant small molecules. Examples of drugs with sugar attachments such as erythromycin and doxorubicin show how sugars can change inactive molecules into antibacterial or anticancer drugs. Finding the correct genetically altered cell-based systems needed for efficient high yield production of small molecule sugar enhanced compounds is the first phase at exploiting sugar enhanced drug discovery beyond what Nature has provided. The broader impacts of this research are found in the enormous potential that sugar enhancement provides to therapeutics. Sugars are critical molecules that regulate a vast array of biological processes and pathways in the human body and play fundamental roles in diseases as well as in drug action. This project will greatly expand the ease and reduce the cost of making, screening and commercially scaling sugar-enhanced small molecule therapeutics.

* Information listed above is at the time of submission. *

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