High throughput salmonella detector

Award Information
Agency: Department of Agriculture
Branch: N/A
Contract: 2016-33610-25685
Agency Tracking Number: 2016-03890
Amount: $599,949.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: 8.5
Solicitation Number: N/A
Solicitation Year: 2016
Award Year: 2016
Award Start Date (Proposal Award Date): 2016-09-01
Award End Date (Contract End Date): 2019-02-28
Small Business Information
11409 VALLEY VIEW RD, Eden Prairie, MN, 55344-0000
DUNS: 114264351
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Maria Torija
 Research Physicist
 (952) 829-9181
Business Contact
 Curt Reynders
Title: Chief Financial Officer
Phone: (952) 829-9217
Email: reynders@nve.com
Research Institution
This Phase II Small Business Innovation Research proposal responds to food safety market needs by developing a high-throughput pathogen detector that will reduce the potential for disease outbreaks and costly food recalls. The device developed in this program addresses a broad sector of food producing markets. This project will focus on detecting live Salmonella organisms in industry-relevant large sample volumes faster, and with significantly higher sensitivity than state-of-the-art methods. The detection method uses DNA and RNA aptamers as biochemical "hooks" between Salmonella and magnetic nanoparticles. The magnetic nanoparticles are then detected by a novel tunneling magnetoresistance (TMR) lab-on-a-chip sensor. The key innovation is a unique microfluidics architecture that localizes Salmonella and bound magnetic nanoparticles to the location on the TMR sensor with the highest sensitivity while dramatically increasing throughput. NVE Corporation has assembled a team of experts from academia and industry for microfluidics design and fabrication, aptamer and magnetic nanoparticle creation, and magnetic TMR sensor production, yielding a highly specific and integrated detection solution. A feasibility prototype was successfully tested in the Phase I program. The goal of the Phase II is the construction of a high-throughput bench-top system with faster, higher-sensitivity detection of Salmonella than otherwise possible.This file MUST be converted to PDF prior to attachment in the electronic application package

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government