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High throughput salmonella detector

Award Information
Agency: Department of Agriculture
Branch: N/A
Contract: 2016-33610-25685
Agency Tracking Number: 2016-03890
Amount: $599,949.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: 8.5
Solicitation Number: N/A
Solicitation Year: 2016
Award Year: 2016
Award Start Date (Proposal Award Date): 2016-09-01
Award End Date (Contract End Date): 2019-02-28
Small Business Information
Eden Prairie, MN 55344-0000
United States
DUNS: 114264351
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Maria Torija
 Research Physicist
 (952) 829-9181
Business Contact
 Curt Reynders
Title: Chief Financial Officer
Phone: (952) 829-9217
Research Institution

This Phase II Small Business Innovation Research proposal responds to food safety market needs by developing a high-throughput pathogen detector that will reduce the potential for disease outbreaks and costly food recalls. The device developed in this program addresses a broad sector of food producing markets. This project will focus on detecting live Salmonella organisms in industry-relevant large sample volumes faster, and with significantly higher sensitivity than state-of-the-art methods. The detection method uses DNA and RNA aptamers as biochemical "hooks" between Salmonella and magnetic nanoparticles. The magnetic nanoparticles are then detected by a novel tunneling magnetoresistance (TMR) lab-on-a-chip sensor. The key innovation is a unique microfluidics architecture that localizes Salmonella and bound magnetic nanoparticles to the location on the TMR sensor with the highest sensitivity while dramatically increasing throughput. NVE Corporation has assembled a team of experts from academia and industry for microfluidics design and fabrication, aptamer and magnetic nanoparticle creation, and magnetic TMR sensor production, yielding a highly specific and integrated detection solution. A feasibility prototype was successfully tested in the Phase I program. The goal of the Phase II is the construction of a high-throughput bench-top system with faster, higher-sensitivity detection of Salmonella than otherwise possible.This file MUST be converted to PDF prior to attachment in the electronic application package

* Information listed above is at the time of submission. *

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